SPEM dysfunction and general schizotypy as measured by the SSQ: a controlled study

D. van Kampen, J.B. Deijen

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Background: SPEM dysfunction is a well-known phenomenon in schizophrenia. The principal aim of the present study was to examine whether SPEM dysfunction is already observable in subjects scoring high on a specific measure of schizotypy (SSQ General Schizotypy) that was selected because of its intimate relationship with schizophrenic prodromal unfolding. Methods: Applying ANOVAs, we determined the relationship of subjects' scores on SSQ General Schizotypy and eye movements elicited by targets of different speed. We also examined whether there exists an association between our schizotypy measure and pupil size. Results: We found more SPEM dysfunction in subjects scoring high on SSQ General Schizotypy than in subjects scoring average on that factor, irrespective of the speed of the target. No relationship was found between baseline pupil size and General Schizotypy. Conclusion: The present study provides additional evidence that SPEM dysfunction is associated with schizotypic features that precede the onset of schizophrenia and is already observable in general population subjects that show these features. © 2009 van Kampen and Deijen; licensee BioMed Central Ltd.
Original languageEnglish
Pages (from-to)27-33
Number of pages6
JournalBMC Neurology
Issue number27
Publication statusPublished - 2009

Bibliographical note

J English Article Deijen, JB, Vrije Univ Amsterdam, Dept Clin Neuropsychol, Boechorststr 1, NL-1081 BT Amsterdam, Netherlands [email protected] [email protected] 67 0 BIOMED CENTRAL LTD LONDON CURRENT SCIENCE GROUP, MIDDLESEX HOUSE, 34-42 CLEVELAND ST, LONDON W1T 4LB, ENGLAND BMC NEUROL JUN 29 Discipline: Clinical Neurology 479WT


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