Spinal cord injury: Can gene therapy with transcription factors drive axon regeneration?

C.L. Attwell

Spinal cord injury: Can gene therapy with transcription factors drive axon regeneration?

C.L. Attwell

Research output: PhD Thesis › PhD Thesis - Research VU Amsterdam, graduation VU Amsterdam

337 Downloads (Pure)

Original language	English
Qualification	PhD
Awarding Institution	Vrije Universiteit Amsterdam
Supervisors/Advisors	Verhaagen, J., Supervisor Mason, M.R.J., Co-supervisor, External person
Award date	12 Sep 2019
Print ISBNs	9789463237307
Publication status	Published - 2019

Keywords

Spinal cord
spinal cord injury
gene therapy
cellular screening
transcription factors
axon regeneration
dorsal root ganglia
functional testing
RNA sequencing

Access to Document

CoverFinal published version, 278 KB
Title pageFinal published version, 167 KB
Abstract dutchFinal published version, 276 KB
Abstract englishFinal published version, 555 KB
Table of contentsFinal published version, 1.05 MB
Preliminary matterFinal published version, 131 KB
Chapter 1: The dorsal column lesion model of spinal cord injury and its use in decipheringFinal published version, 5.07 MB
Chapter 2: Overexpression of ATF3 or the combination of ATF3, c-Jun, STAT3 and Smad1 promotesFinal published version, 2.84 MB
Chapter 6: Evaluation of Five Tests for Sensitivity to Functional DeficitsFinal published version, 2.7 MB
Chapter 7: Summary and general discussionFinal published version, 1.6 MB
Chapter General introduction and outlineFinal published version, 783 KB
appendix Acknowledgements, DankwoordFinal published version, 496 KB

Embargoed Document

Chapter 3: Cellular screening of neurite outgrowth after systematic combinatorial overexpression
Final published version, 2.52 MB
Embargo ends: 12/03/22

Embargoed Document

Chapter 4: Co-overexpression of transcription factors KLF7 and MEF2C promotes
Final published version, 3.54 MB
Embargo ends: 12/03/22

Embargoed Document

Chapter 5: RNA Sequencing of laser captured large-diameter dorsal root ganglia neurons
Final published version, 5.24 MB
Embargo ends: 12/03/22

Cite this

@phdthesis{8f3e2ddc4b4a45b995f26fa7ac05b72b,

title = "Spinal cord injury: Can gene therapy with transcription factors drive axon regeneration?",

keywords = "Spinal cord, spinal cord injury, gene therapy, cellular screening, transcription factors, axon regeneration, dorsal root ganglia, functional testing, RNA sequencing",

author = "C.L. Attwell",

year = "2019",

language = "English",

isbn = "9789463237307",

school = "Vrije Universiteit Amsterdam",

}

TY - THES

T1 - Spinal cord injury

T2 - Can gene therapy with transcription factors drive axon regeneration?

AU - Attwell, C.L.

PY - 2019

Y1 - 2019

KW - Spinal cord

KW - spinal cord injury

KW - gene therapy

KW - cellular screening

KW - transcription factors

KW - axon regeneration

KW - dorsal root ganglia

KW - functional testing

KW - RNA sequencing

M3 - PhD Thesis - Research VU Amsterdam, graduation VU Amsterdam

SN - 9789463237307

ER -