Strain-dependent effects of probiotic lactobacilli on EAE autoimmunity

BM maassen; E. Claassen

doi:10.1016/j.vaccine.2008.02.035

Strain-dependent effects of probiotic lactobacilli on EAE autoimmunity

BM maassen, E. Claassen

Athena Institute

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

In this study we present new data showing strain-specific differences on the effect of commercially available probiotic drinks in an EAE rat autoimmune model for multiple sclerosis. In this particular model, we conclude that these drinks do not enhance but rather suppress the disease. We suggest that conclusions on probiotics are limited to specific strains and models and not generalised. We further suggest that physiological use (normal route, normal dose, normal growth phase, specific strain or substrain/species) is studied in all cases, so as not to overwhelm (high dose) or circumvent natural immune processing. © 2008 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	2056-2057
Number of pages	2
Journal	Vaccine
Volume	26
DOIs	https://doi.org/10.1016/j.vaccine.2008.02.035
Publication status	Published - 2008

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10.1016/j.vaccine.2008.02.035

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title = "Strain-dependent effects of probiotic lactobacilli on EAE autoimmunity",

abstract = "In this study we present new data showing strain-specific differences on the effect of commercially available probiotic drinks in an EAE rat autoimmune model for multiple sclerosis. In this particular model, we conclude that these drinks do not enhance but rather suppress the disease. We suggest that conclusions on probiotics are limited to specific strains and models and not generalised. We further suggest that physiological use (normal route, normal dose, normal growth phase, specific strain or substrain/species) is studied in all cases, so as not to overwhelm (high dose) or circumvent natural immune processing. {\textcopyright} 2008 Elsevier Ltd. All rights reserved.",

author = "BM maassen and E. Claassen",

year = "2008",

doi = "10.1016/j.vaccine.2008.02.035",

language = "English",

volume = "26",

pages = "2056--2057",

journal = "Vaccine",

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T1 - Strain-dependent effects of probiotic lactobacilli on EAE autoimmunity

AU - maassen, BM

AU - Claassen, E.

PY - 2008

Y1 - 2008

N2 - In this study we present new data showing strain-specific differences on the effect of commercially available probiotic drinks in an EAE rat autoimmune model for multiple sclerosis. In this particular model, we conclude that these drinks do not enhance but rather suppress the disease. We suggest that conclusions on probiotics are limited to specific strains and models and not generalised. We further suggest that physiological use (normal route, normal dose, normal growth phase, specific strain or substrain/species) is studied in all cases, so as not to overwhelm (high dose) or circumvent natural immune processing. © 2008 Elsevier Ltd. All rights reserved.

AB - In this study we present new data showing strain-specific differences on the effect of commercially available probiotic drinks in an EAE rat autoimmune model for multiple sclerosis. In this particular model, we conclude that these drinks do not enhance but rather suppress the disease. We suggest that conclusions on probiotics are limited to specific strains and models and not generalised. We further suggest that physiological use (normal route, normal dose, normal growth phase, specific strain or substrain/species) is studied in all cases, so as not to overwhelm (high dose) or circumvent natural immune processing. © 2008 Elsevier Ltd. All rights reserved.

U2 - 10.1016/j.vaccine.2008.02.035

DO - 10.1016/j.vaccine.2008.02.035

M3 - Article

SN - 0264-410X

VL - 26

SP - 2056

EP - 2057

JO - Vaccine

JF - Vaccine

ER -

Strain-dependent effects of probiotic lactobacilli on EAE autoimmunity

Abstract

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