TY - JOUR
T1 - Strain-dependent effects of probiotic lactobacilli on EAE autoimmunity
AU - maassen, BM
AU - Claassen, E.
PY - 2008
Y1 - 2008
N2 - In this study we present new data showing strain-specific differences on the effect of commercially available probiotic drinks in an EAE rat autoimmune model for multiple sclerosis. In this particular model, we conclude that these drinks do not enhance but rather suppress the disease. We suggest that conclusions on probiotics are limited to specific strains and models and not generalised. We further suggest that physiological use (normal route, normal dose, normal growth phase, specific strain or substrain/species) is studied in all cases, so as not to overwhelm (high dose) or circumvent natural immune processing. © 2008 Elsevier Ltd. All rights reserved.
AB - In this study we present new data showing strain-specific differences on the effect of commercially available probiotic drinks in an EAE rat autoimmune model for multiple sclerosis. In this particular model, we conclude that these drinks do not enhance but rather suppress the disease. We suggest that conclusions on probiotics are limited to specific strains and models and not generalised. We further suggest that physiological use (normal route, normal dose, normal growth phase, specific strain or substrain/species) is studied in all cases, so as not to overwhelm (high dose) or circumvent natural immune processing. © 2008 Elsevier Ltd. All rights reserved.
UR - https://www.scopus.com/pages/publications/41549104613
UR - https://www.scopus.com/inward/citedby.url?scp=41549104613&partnerID=8YFLogxK
U2 - 10.1016/j.vaccine.2008.02.035
DO - 10.1016/j.vaccine.2008.02.035
M3 - Article
SN - 0264-410X
VL - 26
SP - 2056
EP - 2057
JO - Vaccine
JF - Vaccine
ER -
