Stratification by Smoking Status Reveals an Association of CHRNA5-A3-B4 Genotype with Body Mass Index in Never Smokers

A.E. Taylor, R.W. Morris, M.E. Fluharty, J.H. Bjorngaard, B.O. Asvold, M.E. Gabrielsen, A. Campbell, R. Marioni, M. Kumari, J. Hällfors, S. Männistö, P. Marques-Vidal, M. Kaakinen, A. Cavadino, I. Postmus, L.L.N. Husemoen, T. Skaaby, T.S. Ahluwalia, J.L. Treur, G. WillemsenC. Dale, S.G. Wannamethee, J. Lahti, A. Palotie, K. Räikkönen, A. Kisialiou, A. McConnachie, S. Padmanabhan, A. Wong, C. Dalgard, L. Paternoster, Y. Ben-Shlomo, J. Tyrrell, L.J. Horwood, D. Fergusson, M.A. Kennedy, T.M. Frayling, E.A. Nohr, L. Christiansen, K. Ohm Kyvik, D Kuh, G. Watt, J. Eriksson, P.H. Whincup, J.M. Vink, D.I. Boomsma, G. Davey Smith, D. Lawlor, A. Linneberg, I. Ford, J.W. Jukema, C. Power, E. Hyppönen, M.R. Järvelin, M. Preisig, K. Borodulin, J. Kaprio, M. Kivimaki, B.H. Smith, C. Hayward, P.R. Romundstad, T.I.A. Sørensen, M.R. Munafo, N. Sattar

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

We previously used a single nucleotide polymorphism (SNP) in the CHRNA5-A3-B4 gene cluster associated with heaviness of smoking within smokers to confirm the causal effect of smoking in reducing body mass index (BMI) in a Mendelian randomisation analysis. While seeking to extend these findings in a larger sample we found that this SNP is associated with 0.74% lower body mass index (BMI) per minor allele in current smokers (95% CI -0.97 to -0.51, P = 2.00×10
Original languageEnglish
Article numbere1004799
Number of pages6
JournalPLoS Genetics
Volume10
Issue number12
DOIs
Publication statusPublished - 2014

Cohort Studies

  • Netherlands Twin Register (NTR)

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