Stratification by Smoking Status Reveals an Association of CHRNA5-A3-B4 Genotype with Body Mass Index in Never Smokers

A.E. Taylor; R.W. Morris; M.E. Fluharty; J.H. Bjorngaard; B.O. Asvold; M.E. Gabrielsen; A. Campbell; R. Marioni; M. Kumari; J. Hällfors; S. Männistö; P. Marques-Vidal; M. Kaakinen; A. Cavadino; I. Postmus; L.L.N. Husemoen; T. Skaaby; T.S. Ahluwalia; J.L. Treur; G. Willemsen; C. Dale; S.G. Wannamethee; J. Lahti; A. Palotie; K. Räikkönen; A. Kisialiou; A. McConnachie; S. Padmanabhan; A. Wong; C. Dalgard; L. Paternoster; Y. Ben-Shlomo; J. Tyrrell; L.J. Horwood; D. Fergusson; M.A. Kennedy; T.M. Frayling; E.A. Nohr; L. Christiansen; K. Ohm Kyvik; D Kuh; G. Watt; J. Eriksson; P.H. Whincup; J.M. Vink; D.I. Boomsma; G. Davey Smith; D. Lawlor; A. Linneberg; I. Ford; J.W. Jukema; C. Power; E. Hyppönen; M.R. Järvelin; M. Preisig; K. Borodulin; J. Kaprio; M. Kivimaki; B.H. Smith; C. Hayward; P.R. Romundstad; T.I.A. Sørensen; M.R. Munafo; N. Sattar

doi:10.1371/journal.pgen.1004799

Stratification by Smoking Status Reveals an Association of CHRNA5-A3-B4 Genotype with Body Mass Index in Never Smokers

A.E. Taylor
, R.W. Morris
, M.E. Fluharty
, J.H. Bjorngaard
, B.O. Asvold
, M.E. Gabrielsen
, A. Campbell
, R. Marioni
, M. Kumari
, J. Hällfors
, S. Männistö
, P. Marques-Vidal
, M. Kaakinen
, A. Cavadino
, I. Postmus
, L.L.N. Husemoen
, T. Skaaby
, T.S. Ahluwalia
, J.L. Treur
, G. Willemsen

C. Dale, S.G. Wannamethee, J. Lahti, A. Palotie, K. Räikkönen, A. Kisialiou, A. McConnachie, S. Padmanabhan, A. Wong, C. Dalgard, L. Paternoster, Y. Ben-Shlomo, J. Tyrrell, L.J. Horwood, D. Fergusson, M.A. Kennedy, T.M. Frayling, E.A. Nohr, L. Christiansen, K. Ohm Kyvik, D Kuh, G. Watt, J. Eriksson, P.H. Whincup, J.M. Vink, D.I. Boomsma, G. Davey Smith, D. Lawlor, A. Linneberg, I. Ford, J.W. Jukema, C. Power, E. Hyppönen, M.R. Järvelin, M. Preisig, K. Borodulin, J. Kaprio, M. Kivimaki, B.H. Smith, C. Hayward, P.R. Romundstad, T.I.A. Sørensen, M.R. Munafo, N. Sattar

Biological Psychology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

We previously used a single nucleotide polymorphism (SNP) in the CHRNA5-A3-B4 gene cluster associated with heaviness of smoking within smokers to confirm the causal effect of smoking in reducing body mass index (BMI) in a Mendelian randomisation analysis. While seeking to extend these findings in a larger sample we found that this SNP is associated with 0.74% lower body mass index (BMI) per minor allele in current smokers (95% CI -0.97 to -0.51, P = 2.00×10

Original language	English
Article number	e1004799
Number of pages	6
Journal	PLoS Genetics
Volume	10
Issue number	12
DOIs	https://doi.org/10.1371/journal.pgen.1004799
Publication status	Published - 2014

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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Taylor, A. E., Morris, R. W., Fluharty, M. E., Bjorngaard, J. H., Asvold, B. O., Gabrielsen, M. E., Campbell, A., Marioni, R., Kumari, M., Hällfors, J., Männistö, S., Marques-Vidal, P., Kaakinen, M., Cavadino, A., Postmus, I., Husemoen, L. L. N., Skaaby, T., Ahluwalia, T. S., Treur, J. L., ... Sattar, N. (2014). Stratification by Smoking Status Reveals an Association of CHRNA5-A3-B4 Genotype with Body Mass Index in Never Smokers. PLoS Genetics, 10(12), Article e1004799. https://doi.org/10.1371/journal.pgen.1004799

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title = "Stratification by Smoking Status Reveals an Association of CHRNA5-A3-B4 Genotype with Body Mass Index in Never Smokers",

abstract = "We previously used a single nucleotide polymorphism (SNP) in the CHRNA5-A3-B4 gene cluster associated with heaviness of smoking within smokers to confirm the causal effect of smoking in reducing body mass index (BMI) in a Mendelian randomisation analysis. While seeking to extend these findings in a larger sample we found that this SNP is associated with 0.74\% lower body mass index (BMI) per minor allele in current smokers (95\% CI -0.97 to -0.51, P = 2.00×10",

author = "A.E. Taylor and R.W. Morris and M.E. Fluharty and J.H. Bjorngaard and B.O. Asvold and M.E. Gabrielsen and A. Campbell and R. Marioni and M. Kumari and J. H{\"a}llfors and S. M{\"a}nnist{\"o} and P. Marques-Vidal and M. Kaakinen and A. Cavadino and I. Postmus and L.L.N. Husemoen and T. Skaaby and T.S. Ahluwalia and J.L. Treur and G. Willemsen and C. Dale and S.G. Wannamethee and J. Lahti and A. Palotie and K. R{\"a}ikk{\"o}nen and A. Kisialiou and A. McConnachie and S. Padmanabhan and A. Wong and C. Dalgard and L. Paternoster and Y. Ben-Shlomo and J. Tyrrell and L.J. Horwood and D. Fergusson and M.A. Kennedy and T.M. Frayling and E.A. Nohr and L. Christiansen and \{Ohm Kyvik\}, K. and D Kuh and G. Watt and J. Eriksson and P.H. Whincup and J.M. Vink and D.I. Boomsma and \{Davey Smith\}, G. and D. Lawlor and A. Linneberg and I. Ford and J.W. Jukema and C. Power and E. Hypp{\"o}nen and M.R. J{\"a}rvelin and M. Preisig and K. Borodulin and J. Kaprio and M. Kivimaki and B.H. Smith and C. Hayward and P.R. Romundstad and T.I.A. S{\o}rensen and M.R. Munafo and N. Sattar",

year = "2014",

doi = "10.1371/journal.pgen.1004799",

language = "English",

volume = "10",

journal = "PLoS Genetics",

issn = "1553-7390",

publisher = "Public Library of Science",

number = "12",

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Taylor, AE, Morris, RW, Fluharty, ME, Bjorngaard, JH, Asvold, BO, Gabrielsen, ME, Campbell, A, Marioni, R, Kumari, M, Hällfors, J, Männistö, S, Marques-Vidal, P, Kaakinen, M, Cavadino, A, Postmus, I, Husemoen, LLN, Skaaby, T, Ahluwalia, TS, Treur, JL, Willemsen, G, Dale, C, Wannamethee, SG, Lahti, J, Palotie, A, Räikkönen, K, Kisialiou, A, McConnachie, A, Padmanabhan, S, Wong, A, Dalgard, C, Paternoster, L, Ben-Shlomo, Y, Tyrrell, J, Horwood, LJ, Fergusson, D, Kennedy, MA, Frayling, TM, Nohr, EA, Christiansen, L, Ohm Kyvik, K, Kuh, D, Watt, G, Eriksson, J, Whincup, PH, Vink, JM, Boomsma, DI, Davey Smith, G, Lawlor, D, Linneberg, A, Ford, I, Jukema, JW, Power, C, Hyppönen, E, Järvelin, MR, Preisig, M, Borodulin, K, Kaprio, J, Kivimaki, M, Smith, BH, Hayward, C, Romundstad, PR, Sørensen, TIA, Munafo, MR & Sattar, N 2014, 'Stratification by Smoking Status Reveals an Association of CHRNA5-A3-B4 Genotype with Body Mass Index in Never Smokers', PLoS Genetics, vol. 10, no. 12, e1004799. https://doi.org/10.1371/journal.pgen.1004799

TY - JOUR

T1 - Stratification by Smoking Status Reveals an Association of CHRNA5-A3-B4 Genotype with Body Mass Index in Never Smokers

AU - Taylor, A.E.

AU - Morris, R.W.

AU - Fluharty, M.E.

AU - Bjorngaard, J.H.

AU - Asvold, B.O.

AU - Gabrielsen, M.E.

AU - Campbell, A.

AU - Marioni, R.

AU - Kumari, M.

AU - Hällfors, J.

AU - Männistö, S.

AU - Marques-Vidal, P.

AU - Kaakinen, M.

AU - Cavadino, A.

AU - Postmus, I.

AU - Husemoen, L.L.N.

AU - Skaaby, T.

AU - Ahluwalia, T.S.

AU - Treur, J.L.

AU - Willemsen, G.

AU - Dale, C.

AU - Wannamethee, S.G.

AU - Lahti, J.

AU - Palotie, A.

AU - Räikkönen, K.

AU - Kisialiou, A.

AU - McConnachie, A.

AU - Padmanabhan, S.

AU - Wong, A.

AU - Dalgard, C.

AU - Paternoster, L.

AU - Ben-Shlomo, Y.

AU - Tyrrell, J.

AU - Horwood, L.J.

AU - Fergusson, D.

AU - Kennedy, M.A.

AU - Frayling, T.M.

AU - Nohr, E.A.

AU - Christiansen, L.

AU - Ohm Kyvik, K.

AU - Kuh, D

AU - Watt, G.

AU - Eriksson, J.

AU - Whincup, P.H.

AU - Vink, J.M.

AU - Boomsma, D.I.

AU - Davey Smith, G.

AU - Lawlor, D.

AU - Linneberg, A.

AU - Ford, I.

AU - Jukema, J.W.

AU - Power, C.

AU - Hyppönen, E.

AU - Järvelin, M.R.

AU - Preisig, M.

AU - Borodulin, K.

AU - Kaprio, J.

AU - Kivimaki, M.

AU - Smith, B.H.

AU - Hayward, C.

AU - Romundstad, P.R.

AU - Sørensen, T.I.A.

AU - Munafo, M.R.

AU - Sattar, N.

PY - 2014

Y1 - 2014

N2 - We previously used a single nucleotide polymorphism (SNP) in the CHRNA5-A3-B4 gene cluster associated with heaviness of smoking within smokers to confirm the causal effect of smoking in reducing body mass index (BMI) in a Mendelian randomisation analysis. While seeking to extend these findings in a larger sample we found that this SNP is associated with 0.74% lower body mass index (BMI) per minor allele in current smokers (95% CI -0.97 to -0.51, P = 2.00×10

AB - We previously used a single nucleotide polymorphism (SNP) in the CHRNA5-A3-B4 gene cluster associated with heaviness of smoking within smokers to confirm the causal effect of smoking in reducing body mass index (BMI) in a Mendelian randomisation analysis. While seeking to extend these findings in a larger sample we found that this SNP is associated with 0.74% lower body mass index (BMI) per minor allele in current smokers (95% CI -0.97 to -0.51, P = 2.00×10

U2 - 10.1371/journal.pgen.1004799

DO - 10.1371/journal.pgen.1004799

M3 - Article

SN - 1553-7390

VL - 10

JO - PLoS Genetics

JF - PLoS Genetics

IS - 12

M1 - e1004799

ER -

Stratification by Smoking Status Reveals an Association of CHRNA5-A3-B4 Genotype with Body Mass Index in Never Smokers

Abstract

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