Abstract
Individual differences in the response of the stress system to hormonal changes during pregnancy and the postpartum period render some women susceptible to developing depression. The present study sought to investigate peripartum depression and stress hormones in relation to stress-related genotypes. The Edinburgh Postnatal Depression Scale was used to assess peripartum depressive symptoms in a sample of 1629 women, followed from pregnancy week seventeen to six months postpartum. Genotypes of ninety-four haplotype-tag single nucleotide polymorphisms (SNPs) in sixteen genes of the hypothalamus-pituitary-adrenal axis pathway were analyzed and data on psychosocial and demographic factors was collected. In sub-studies, salivary cortisol awakening response in gestational week 35–39, salivary evening cortisol levels in gestational week 36 and postpartum week 6, and blood cortisol and cortisone levels in gestational week 35–39 were analyzed. SNP-set kernel association tests were performed at the gene-level, considering psychosocial and demographic factors, followed by post-hoc analyses of SNPs of significant genes. Statistically significant findings at the 0.05 p-level included SNPs in the hydroxysteroid 11-beta dehydrogenase 1 (HSD11B1) gene in relation to self-rated depression scores in postpartum week six among all participants, and serpin family A member 6 (SERPINA6) gene at the same time-point among women with de novo onset of postpartum depression. SNPs in these genes also associated with stress hormone levels during pregnancy. The present study adds knowledge to the neurobiological basis of peripartum depression by systematically assessing SNPs in stress-regulatory genes and stress-hormone levels in a population-based sample of women.
| Language | English |
|---|---|
| Pages | 296-305 |
| Number of pages | 10 |
| Journal | Psychoneuroendocrinology |
| Volume | 103 |
| Early online date | 7 Feb 2019 |
| DOIs | |
| Publication status | Published - May 2019 |
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Keywords
- Cortisol
- Gene
- Hormones
- Hypothalamic-pituitary-adrenal axis
- Perinatal depression
- Postpartum depression
- Single nucleotide polymorphism
- Stress
Cite this
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Stress-related genetic polymorphisms in association with peripartum depression symptoms and stress hormones : A longitudinal population-based study. / Skalkidou, Alkistis; Poromaa, Inger Sundström; Iliadis, Stavros I.; Huizink, Anja C.; Hellgren, Charlotte; Freyhult, Eva; Comasco, Erika.
In: Psychoneuroendocrinology, Vol. 103, 05.2019, p. 296-305.Research output: Contribution to Journal › Article › Academic › peer-review
TY - JOUR
T1 - Stress-related genetic polymorphisms in association with peripartum depression symptoms and stress hormones
T2 - Psychoneuroendocrinology
AU - Skalkidou, Alkistis
AU - Poromaa, Inger Sundström
AU - Iliadis, Stavros I.
AU - Huizink, Anja C.
AU - Hellgren, Charlotte
AU - Freyhult, Eva
AU - Comasco, Erika
PY - 2019/5
Y1 - 2019/5
N2 - Individual differences in the response of the stress system to hormonal changes during pregnancy and the postpartum period render some women susceptible to developing depression. The present study sought to investigate peripartum depression and stress hormones in relation to stress-related genotypes. The Edinburgh Postnatal Depression Scale was used to assess peripartum depressive symptoms in a sample of 1629 women, followed from pregnancy week seventeen to six months postpartum. Genotypes of ninety-four haplotype-tag single nucleotide polymorphisms (SNPs) in sixteen genes of the hypothalamus-pituitary-adrenal axis pathway were analyzed and data on psychosocial and demographic factors was collected. In sub-studies, salivary cortisol awakening response in gestational week 35–39, salivary evening cortisol levels in gestational week 36 and postpartum week 6, and blood cortisol and cortisone levels in gestational week 35–39 were analyzed. SNP-set kernel association tests were performed at the gene-level, considering psychosocial and demographic factors, followed by post-hoc analyses of SNPs of significant genes. Statistically significant findings at the 0.05 p-level included SNPs in the hydroxysteroid 11-beta dehydrogenase 1 (HSD11B1) gene in relation to self-rated depression scores in postpartum week six among all participants, and serpin family A member 6 (SERPINA6) gene at the same time-point among women with de novo onset of postpartum depression. SNPs in these genes also associated with stress hormone levels during pregnancy. The present study adds knowledge to the neurobiological basis of peripartum depression by systematically assessing SNPs in stress-regulatory genes and stress-hormone levels in a population-based sample of women.
AB - Individual differences in the response of the stress system to hormonal changes during pregnancy and the postpartum period render some women susceptible to developing depression. The present study sought to investigate peripartum depression and stress hormones in relation to stress-related genotypes. The Edinburgh Postnatal Depression Scale was used to assess peripartum depressive symptoms in a sample of 1629 women, followed from pregnancy week seventeen to six months postpartum. Genotypes of ninety-four haplotype-tag single nucleotide polymorphisms (SNPs) in sixteen genes of the hypothalamus-pituitary-adrenal axis pathway were analyzed and data on psychosocial and demographic factors was collected. In sub-studies, salivary cortisol awakening response in gestational week 35–39, salivary evening cortisol levels in gestational week 36 and postpartum week 6, and blood cortisol and cortisone levels in gestational week 35–39 were analyzed. SNP-set kernel association tests were performed at the gene-level, considering psychosocial and demographic factors, followed by post-hoc analyses of SNPs of significant genes. Statistically significant findings at the 0.05 p-level included SNPs in the hydroxysteroid 11-beta dehydrogenase 1 (HSD11B1) gene in relation to self-rated depression scores in postpartum week six among all participants, and serpin family A member 6 (SERPINA6) gene at the same time-point among women with de novo onset of postpartum depression. SNPs in these genes also associated with stress hormone levels during pregnancy. The present study adds knowledge to the neurobiological basis of peripartum depression by systematically assessing SNPs in stress-regulatory genes and stress-hormone levels in a population-based sample of women.
KW - Cortisol
KW - Gene
KW - Hormones
KW - Hypothalamic-pituitary-adrenal axis
KW - Perinatal depression
KW - Postpartum depression
KW - Single nucleotide polymorphism
KW - Stress
UR - http://www.scopus.com/inward/record.url?scp=85061524516&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85061524516&partnerID=8YFLogxK
U2 - 10.1016/j.psyneuen.2019.02.002
DO - 10.1016/j.psyneuen.2019.02.002
M3 - Article
VL - 103
SP - 296
EP - 305
JO - Psychoneuroendocrinology
JF - Psychoneuroendocrinology
SN - 0306-4530
ER -