Structural aspects of antioxidant activity of flavonoids.

S.A.B.E. van Acker, D.J. van den Berg, M.N.J.L. Tromp, D.H. Griffioen, W.P. van Bennekom, W.J.F. van der Vijgh, A. Bast

    Research output: Contribution to JournalArticleAcademicpeer-review

    Abstract

    Flavonoids, a group of naturally occurring antioxidants and iron chelators, might be used as cardioprotective agents in doxorubicin-induced cardiotoxicity, which is believed to be caused by the formation of oxygen free radicals. To investigate the underlying molecular mechanism, we tested a large group of flavonoids from all major structural subclasses on their ability to inhibit doxorubicin (enzymatically)-induced and Fe
    Original languageEnglish
    Pages (from-to)331-342
    JournalFree Radical Biology and Medicine
    Volume20
    Issue number3
    DOIs
    Publication statusPublished - 1996

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