Structural aspects of antioxidant activity of flavonoids.

S.A.B.E. van Acker; D.J. van den Berg; M.N.J.L. Tromp; D.H. Griffioen; W.P. van Bennekom; W.J.F. van der Vijgh; A. Bast

doi:10.1016/0891-5849(95)02047-0

Structural aspects of antioxidant activity of flavonoids.

S.A.B.E. van Acker, D.J. van den Berg, M.N.J.L. Tromp, D.H. Griffioen, W.P. van Bennekom, W.J.F. van der Vijgh, A. Bast

Medicinal chemistry

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Flavonoids, a group of naturally occurring antioxidants and iron chelators, might be used as cardioprotective agents in doxorubicin-induced cardiotoxicity, which is believed to be caused by the formation of oxygen free radicals. To investigate the underlying molecular mechanism, we tested a large group of flavonoids from all major structural subclasses on their ability to inhibit doxorubicin (enzymatically)-induced and Fe

Original language	English
Pages (from-to)	331-342
Journal	Free Radical Biology and Medicine
Volume	20
Issue number	3
DOIs	https://doi.org/10.1016/0891-5849(95)02047-0
Publication status	Published - 1996

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title = "Structural aspects of antioxidant activity of flavonoids.",

abstract = "Flavonoids, a group of naturally occurring antioxidants and iron chelators, might be used as cardioprotective agents in doxorubicin-induced cardiotoxicity, which is believed to be caused by the formation of oxygen free radicals. To investigate the underlying molecular mechanism, we tested a large group of flavonoids from all major structural subclasses on their ability to inhibit doxorubicin (enzymatically)-induced and Fe",

author = "{van Acker}, S.A.B.E. and {van den Berg}, D.J. and M.N.J.L. Tromp and D.H. Griffioen and {van Bennekom}, W.P. and {van der Vijgh}, W.J.F. and A. Bast",

year = "1996",

doi = "10.1016/0891-5849(95)02047-0",

language = "English",

volume = "20",

pages = "331--342",

journal = "Free Radical Biology and Medicine",

issn = "0891-5849",

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T1 - Structural aspects of antioxidant activity of flavonoids.

AU - van Acker, S.A.B.E.

AU - van den Berg, D.J.

AU - Tromp, M.N.J.L.

AU - Griffioen, D.H.

AU - van Bennekom, W.P.

AU - van der Vijgh, W.J.F.

AU - Bast, A.

PY - 1996

Y1 - 1996

N2 - Flavonoids, a group of naturally occurring antioxidants and iron chelators, might be used as cardioprotective agents in doxorubicin-induced cardiotoxicity, which is believed to be caused by the formation of oxygen free radicals. To investigate the underlying molecular mechanism, we tested a large group of flavonoids from all major structural subclasses on their ability to inhibit doxorubicin (enzymatically)-induced and Fe

AB - Flavonoids, a group of naturally occurring antioxidants and iron chelators, might be used as cardioprotective agents in doxorubicin-induced cardiotoxicity, which is believed to be caused by the formation of oxygen free radicals. To investigate the underlying molecular mechanism, we tested a large group of flavonoids from all major structural subclasses on their ability to inhibit doxorubicin (enzymatically)-induced and Fe

U2 - 10.1016/0891-5849(95)02047-0

DO - 10.1016/0891-5849(95)02047-0

M3 - Article

VL - 20

SP - 331

EP - 342

JO - Free Radical Biology and Medicine

JF - Free Radical Biology and Medicine

SN - 0891-5849

IS - 3

ER -

Structural aspects of antioxidant activity of flavonoids.

Abstract

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