Structural aspects of antioxidant activity of flavonoids.

S.A.B.E. van Acker, D.J. van den Berg, M.N.J.L. Tromp, D.H. Griffioen, W.P. van Bennekom, W.J.F. van der Vijgh, A. Bast

Research output: Contribution to JournalArticleAcademicpeer-review


Flavonoids, a group of naturally occurring antioxidants and iron chelators, might be used as cardioprotective agents in doxorubicin-induced cardiotoxicity, which is believed to be caused by the formation of oxygen free radicals. To investigate the underlying molecular mechanism, we tested a large group of flavonoids from all major structural subclasses on their ability to inhibit doxorubicin (enzymatically)-induced and Fe
Original languageEnglish
Pages (from-to)331-342
JournalFree Radical Biology and Medicine
Issue number3
Publication statusPublished - 1996


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