Abstract
The SARS-CoV-1/SARS-CoV-2 main protease cleaves the nascent viral polyproteins into biologically functional molecules, which are essential for viral reproduction inside the host cell. With more than 500 crystal structures available, it is one of the most heavily researched coronavirus proteins and a popular drug target. This review focuses on putting the function and structure of the main protease into a historical perspective, highlighting the structure-based design of inhibitors of the main protease and discussing potential future research directions.
| Original language | English |
|---|---|
| Pages (from-to) | 76-101 |
| Number of pages | 26 |
| Journal | Crystallography Reviews |
| Volume | 29 |
| Issue number | 2 |
| Early online date | 23 Jun 2023 |
| DOIs | |
| Publication status | Published - 2023 |
Bibliographical note
Publisher Copyright:© 2023 Informa UK Limited, trading as Taylor & Francis Group.
Funding
This work was supported by the German Federal Ministry of Education and Research [grant number 05K19WWA], [grant number 05K22GU5] and Deutsche Forschungsgemeinschaft [project TH2135/2-1]. N.M.P recognizes funding from a Veni Fellowship [no. VI.Veni.192.143] from the. We thank Rosemary Wilson for proofreading. All figures are courtesy of the Coronavirus Structural Task Force (insidecorona.net) which retains copyright for both the text and the figures.
| Funders | Funder number |
|---|---|
| Coronavirus Structural Task Force | |
| Deutsche Forschungsgemeinschaft | TH2135/2-1, VI.Veni.192.143 |
| Bundesministerium für Bildung und Forschung | 05K22GU5, 05K19WWA |
Keywords
- COVID-19
- inhibitors
- ligand screening
- main protease
- SARS-CoV-2