Structure-function mapping using a three-dimensional neuroretinal rim parameter derived from spectral domain optical coherence tomography volume scans

Ali Riza Cenk Celebi, Elli A. Park, Alice Chandra Verticchio Vercellin, Edem Tsikata, Ramon Lee, Eric Shieh, Hussein Antar, Madeline Freeman, Jing Zhang, Christian Que, Huseyin Simavli, Michael McClurkin, Rong Guo, Tobias Elze, Johannes F. De Boer, Teresa C. Chen*

*Corresponding author for this work

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Purpose: To assess the structure-function relationship in glaucoma using Humphrey visual field (HVF) perimetry and a three-dimensional neuroretinal rim parameter derived from spectral domain optical coherence tomography (SD-OCT) volume scans.

Methods: Structure-function correlation was analyzed globally and regionally (four quadrants and four sectors). Structural data included peripapillary retinal nerve fiber layer (RNFL) thickness and minimum distance band (MDB) neuroretinal rim thick-ness, defined as the shortest distance between the inner cup surface and the outer retinal pigment epithelium/Bruch’s membrane complex. Logarithmic regression analyses were performed and Pearson correlation coefficients determined to assess relationship strength.

Results: The study consisted of 102 open-angle glaucoma patients and 58 healthy subjects. The Pearson correlation coefficient for global MDB thickness (R = 0.585) was higher than for global RNFL thickness (R = 0.492), but the difference was not statisti-cally significant (P = 0.18). The correlation coefficients for regional MDB thicknesses and corresponding HVF sensitivities were higher than those for regional RNFL thicknesses and HVF in six out of eight regions (P = 0.08 to 0.47). In the remaining two out of eight regions, the correlation coefficients were higher for RNFL thickness than for MDB thickness (P = 0.15 to 0.20).

Conclusions: Three-dimensional MDB neuroretinal rim thickness relates to visual function as strongly as the most commonly used SD-OCT parameter for glaucoma, two-dimensional peripapillary RNFL thickness.

Original languageEnglish
Article number28
Pages (from-to)1-13
Number of pages13
JournalTranslational Vision Science and Technology
Volume10
Issue number6
DOIs
Publication statusPublished - May 2021

Bibliographical note

Funding Information:
T.C.C. received funding from the National Institutes of Health UL1 RR 025758, Massachusetts Lions Eye Research Fund (New Bedford, Massachusetts), American Glaucoma Society Mid-Career Award (San Francisco, California), Fidelity Charitable Fund (Harvard University), and Department of Defense Small Business Innovation Research DHP15-016.

Publisher Copyright:
© 2021 The Authors.

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

Keywords

  • Glaucoma
  • Minimum distance band
  • Retinal nerve fiber layer
  • Spectral domain optical coherence tomography
  • Structure-function relationship

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