Structure-function mapping using a three-dimensional neuroretinal rim parameter derived from spectral domain optical coherence tomography volume scans

Ali Riza Cenk Celebi; Elli A. Park; Alice Chandra Verticchio Vercellin; Edem Tsikata; Ramon Lee; Eric Shieh; Hussein Antar; Madeline Freeman; Jing Zhang; Christian Que; Huseyin Simavli; Michael McClurkin; Rong Guo; Tobias Elze; Johannes F. De Boer; Teresa C. Chen

doi:10.1167/TVST.10.6.28

Structure-function mapping using a three-dimensional neuroretinal rim parameter derived from spectral domain optical coherence tomography volume scans

Ali Riza Cenk Celebi, Elli A. Park, Alice Chandra Verticchio Vercellin, Edem Tsikata, Ramon Lee, Eric Shieh, Hussein Antar, Madeline Freeman, Jing Zhang, Christian Que, Huseyin Simavli, Michael McClurkin, Rong Guo, Tobias Elze, Johannes F. De Boer, Teresa C. Chen^*

^*Corresponding author for this work

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Purpose: To assess the structure-function relationship in glaucoma using Humphrey visual field (HVF) perimetry and a three-dimensional neuroretinal rim parameter derived from spectral domain optical coherence tomography (SD-OCT) volume scans.

Methods: Structure-function correlation was analyzed globally and regionally (four quadrants and four sectors). Structural data included peripapillary retinal nerve fiber layer (RNFL) thickness and minimum distance band (MDB) neuroretinal rim thick-ness, defined as the shortest distance between the inner cup surface and the outer retinal pigment epithelium/Bruch’s membrane complex. Logarithmic regression analyses were performed and Pearson correlation coefficients determined to assess relationship strength.

Results: The study consisted of 102 open-angle glaucoma patients and 58 healthy subjects. The Pearson correlation coefficient for global MDB thickness (R = 0.585) was higher than for global RNFL thickness (R = 0.492), but the difference was not statisti-cally significant (P = 0.18). The correlation coefficients for regional MDB thicknesses and corresponding HVF sensitivities were higher than those for regional RNFL thicknesses and HVF in six out of eight regions (P = 0.08 to 0.47). In the remaining two out of eight regions, the correlation coefficients were higher for RNFL thickness than for MDB thickness (P = 0.15 to 0.20).

Conclusions: Three-dimensional MDB neuroretinal rim thickness relates to visual function as strongly as the most commonly used SD-OCT parameter for glaucoma, two-dimensional peripapillary RNFL thickness.

Original language	English
Article number	28
Pages (from-to)	1-13
Number of pages	13
Journal	Translational Vision Science and Technology
Volume	10
Issue number	6
DOIs	https://doi.org/10.1167/TVST.10.6.28
Publication status	Published - May 2021

Bibliographical note

Funding Information:
T.C.C. received funding from the National Institutes of Health UL1 RR 025758, Massachusetts Lions Eye Research Fund (New Bedford, Massachusetts), American Glaucoma Society Mid-Career Award (San Francisco, California), Fidelity Charitable Fund (Harvard University), and Department of Defense Small Business Innovation Research DHP15-016.

Publisher Copyright:
© 2021 The Authors.

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

Funding

T.C.C. received funding from the National Institutes of Health UL1 RR 025758, Massachusetts Lions Eye Research Fund (New Bedford, Massachusetts), American Glaucoma Society Mid-Career Award (San Francisco, California), Fidelity Charitable Fund (Harvard University), and Department of Defense Small Business Innovation Research DHP15-016.

Funders	Funder number
Department of Defense Small Business Innovation Research	DHP15-016
Fidelity Charitable Fund
National Institutes of Health	UL1 RR 025758
National Institutes of Health
Massachusetts Lions Eye Research Fund
American Glaucoma Society

Keywords

Glaucoma
Minimum distance band
Retinal nerve fiber layer
Spectral domain optical coherence tomography
Structure-function relationship

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Celebi, A. R. C., Park, E. A., Vercellin, A. C. V., Tsikata, E., Lee, R., Shieh, E., Antar, H., Freeman, M., Zhang, J., Que, C., Simavli, H., McClurkin, M., Guo, R., Elze, T., De Boer, J. F., & Chen, T. C. (2021). Structure-function mapping using a three-dimensional neuroretinal rim parameter derived from spectral domain optical coherence tomography volume scans. Translational Vision Science and Technology, 10(6), 1-13. Article 28. https://doi.org/10.1167/TVST.10.6.28

@article{4caf4b3af4234383986f91625c811b3b,

title = "Structure-function mapping using a three-dimensional neuroretinal rim parameter derived from spectral domain optical coherence tomography volume scans",

abstract = "Purpose: To assess the structure-function relationship in glaucoma using Humphrey visual field (HVF) perimetry and a three-dimensional neuroretinal rim parameter derived from spectral domain optical coherence tomography (SD-OCT) volume scans.Methods: Structure-function correlation was analyzed globally and regionally (four quadrants and four sectors). Structural data included peripapillary retinal nerve fiber layer (RNFL) thickness and minimum distance band (MDB) neuroretinal rim thick-ness, defined as the shortest distance between the inner cup surface and the outer retinal pigment epithelium/Bruch{\textquoteright}s membrane complex. Logarithmic regression analyses were performed and Pearson correlation coefficients determined to assess relationship strength.Results: The study consisted of 102 open-angle glaucoma patients and 58 healthy subjects. The Pearson correlation coefficient for global MDB thickness (R = 0.585) was higher than for global RNFL thickness (R = 0.492), but the difference was not statisti-cally significant (P = 0.18). The correlation coefficients for regional MDB thicknesses and corresponding HVF sensitivities were higher than those for regional RNFL thicknesses and HVF in six out of eight regions (P = 0.08 to 0.47). In the remaining two out of eight regions, the correlation coefficients were higher for RNFL thickness than for MDB thickness (P = 0.15 to 0.20).Conclusions: Three-dimensional MDB neuroretinal rim thickness relates to visual function as strongly as the most commonly used SD-OCT parameter for glaucoma, two-dimensional peripapillary RNFL thickness.",

keywords = "Glaucoma, Minimum distance band, Retinal nerve fiber layer, Spectral domain optical coherence tomography, Structure-function relationship",

author = "Celebi, {Ali Riza Cenk} and Park, {Elli A.} and Vercellin, {Alice Chandra Verticchio} and Edem Tsikata and Ramon Lee and Eric Shieh and Hussein Antar and Madeline Freeman and Jing Zhang and Christian Que and Huseyin Simavli and Michael McClurkin and Rong Guo and Tobias Elze and {De Boer}, {Johannes F.} and Chen, {Teresa C.}",

note = "Funding Information: T.C.C. received funding from the National Institutes of Health UL1 RR 025758, Massachusetts Lions Eye Research Fund (New Bedford, Massachusetts), American Glaucoma Society Mid-Career Award (San Francisco, California), Fidelity Charitable Fund (Harvard University), and Department of Defense Small Business Innovation Research DHP15-016. Publisher Copyright: {\textcopyright} 2021 The Authors. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

year = "2021",

month = may,

doi = "10.1167/TVST.10.6.28",

language = "English",

volume = "10",

pages = "1--13",

journal = "Translational Vision Science and Technology",

issn = "2164-2591",

publisher = "Association for Research in Vision and Ophthalmology Inc.",

number = "6",

}

Celebi, ARC, Park, EA, Vercellin, ACV, Tsikata, E, Lee, R, Shieh, E, Antar, H, Freeman, M, Zhang, J, Que, C, Simavli, H, McClurkin, M, Guo, R, Elze, T, De Boer, JF & Chen, TC 2021, 'Structure-function mapping using a three-dimensional neuroretinal rim parameter derived from spectral domain optical coherence tomography volume scans', Translational Vision Science and Technology, vol. 10, no. 6, 28, pp. 1-13. https://doi.org/10.1167/TVST.10.6.28

Structure-function mapping using a three-dimensional neuroretinal rim parameter derived from spectral domain optical coherence tomography volume scans. / Celebi, Ali Riza Cenk; Park, Elli A.; Vercellin, Alice Chandra Verticchio et al.
In: Translational Vision Science and Technology, Vol. 10, No. 6, 28, 05.2021, p. 1-13.

Research output: Contribution to Journal › Article › Academic › peer-review

TY - JOUR

T1 - Structure-function mapping using a three-dimensional neuroretinal rim parameter derived from spectral domain optical coherence tomography volume scans

AU - Celebi, Ali Riza Cenk

AU - Park, Elli A.

AU - Vercellin, Alice Chandra Verticchio

AU - Tsikata, Edem

AU - Lee, Ramon

AU - Shieh, Eric

AU - Antar, Hussein

AU - Freeman, Madeline

AU - Zhang, Jing

AU - Que, Christian

AU - Simavli, Huseyin

AU - McClurkin, Michael

AU - Guo, Rong

AU - Elze, Tobias

AU - De Boer, Johannes F.

AU - Chen, Teresa C.

N1 - Funding Information: T.C.C. received funding from the National Institutes of Health UL1 RR 025758, Massachusetts Lions Eye Research Fund (New Bedford, Massachusetts), American Glaucoma Society Mid-Career Award (San Francisco, California), Fidelity Charitable Fund (Harvard University), and Department of Defense Small Business Innovation Research DHP15-016. Publisher Copyright: © 2021 The Authors. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/5

Y1 - 2021/5

N2 - Purpose: To assess the structure-function relationship in glaucoma using Humphrey visual field (HVF) perimetry and a three-dimensional neuroretinal rim parameter derived from spectral domain optical coherence tomography (SD-OCT) volume scans.Methods: Structure-function correlation was analyzed globally and regionally (four quadrants and four sectors). Structural data included peripapillary retinal nerve fiber layer (RNFL) thickness and minimum distance band (MDB) neuroretinal rim thick-ness, defined as the shortest distance between the inner cup surface and the outer retinal pigment epithelium/Bruch’s membrane complex. Logarithmic regression analyses were performed and Pearson correlation coefficients determined to assess relationship strength.Results: The study consisted of 102 open-angle glaucoma patients and 58 healthy subjects. The Pearson correlation coefficient for global MDB thickness (R = 0.585) was higher than for global RNFL thickness (R = 0.492), but the difference was not statisti-cally significant (P = 0.18). The correlation coefficients for regional MDB thicknesses and corresponding HVF sensitivities were higher than those for regional RNFL thicknesses and HVF in six out of eight regions (P = 0.08 to 0.47). In the remaining two out of eight regions, the correlation coefficients were higher for RNFL thickness than for MDB thickness (P = 0.15 to 0.20).Conclusions: Three-dimensional MDB neuroretinal rim thickness relates to visual function as strongly as the most commonly used SD-OCT parameter for glaucoma, two-dimensional peripapillary RNFL thickness.

AB - Purpose: To assess the structure-function relationship in glaucoma using Humphrey visual field (HVF) perimetry and a three-dimensional neuroretinal rim parameter derived from spectral domain optical coherence tomography (SD-OCT) volume scans.Methods: Structure-function correlation was analyzed globally and regionally (four quadrants and four sectors). Structural data included peripapillary retinal nerve fiber layer (RNFL) thickness and minimum distance band (MDB) neuroretinal rim thick-ness, defined as the shortest distance between the inner cup surface and the outer retinal pigment epithelium/Bruch’s membrane complex. Logarithmic regression analyses were performed and Pearson correlation coefficients determined to assess relationship strength.Results: The study consisted of 102 open-angle glaucoma patients and 58 healthy subjects. The Pearson correlation coefficient for global MDB thickness (R = 0.585) was higher than for global RNFL thickness (R = 0.492), but the difference was not statisti-cally significant (P = 0.18). The correlation coefficients for regional MDB thicknesses and corresponding HVF sensitivities were higher than those for regional RNFL thicknesses and HVF in six out of eight regions (P = 0.08 to 0.47). In the remaining two out of eight regions, the correlation coefficients were higher for RNFL thickness than for MDB thickness (P = 0.15 to 0.20).Conclusions: Three-dimensional MDB neuroretinal rim thickness relates to visual function as strongly as the most commonly used SD-OCT parameter for glaucoma, two-dimensional peripapillary RNFL thickness.

KW - Glaucoma

KW - Minimum distance band

KW - Retinal nerve fiber layer

KW - Spectral domain optical coherence tomography

KW - Structure-function relationship

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DO - 10.1167/TVST.10.6.28

M3 - Article

AN - SCOPUS:85107738763

SN - 2164-2591

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JO - Translational Vision Science and Technology

JF - Translational Vision Science and Technology

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Structure-function mapping using a three-dimensional neuroretinal rim parameter derived from spectral domain optical coherence tomography volume scans

Abstract

Bibliographical note

Funding

Keywords

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