TY - JOUR
T1 - Structure of human transthyretin complexed with bromophenols: a new mode of binding
AU - Ghosh, M.
AU - Meerts, I.A.T.M.
AU - Cook, A.
AU - Bergman, A.
AU - Brouwer, A.
AU - Johnson, L.N.
PY - 2000
Y1 - 2000
N2 - The binding of two organohalogen substances, pentabromophenol (PBP) and 2,4,6-tribromophenol (TBP), to human transthyretin (TTR), a thyroid hormone transport protein, has been studied by in vitro competitive binding assays and by X-ray crystallography. Both compounds bind to TTR with high affinity, in competition with the natural ligand thyroxine (T
AB - The binding of two organohalogen substances, pentabromophenol (PBP) and 2,4,6-tribromophenol (TBP), to human transthyretin (TTR), a thyroid hormone transport protein, has been studied by in vitro competitive binding assays and by X-ray crystallography. Both compounds bind to TTR with high affinity, in competition with the natural ligand thyroxine (T
U2 - 10.1107/S0907444900008568
DO - 10.1107/S0907444900008568
M3 - Article
SN - 0907-4449
VL - 56
SP - 1085
EP - 1095
JO - Acta Crystallographica Section D. Biological Crystallography
JF - Acta Crystallographica Section D. Biological Crystallography
ER -