Studies on the inhibition of human cytochromes P450 by selenocysteine Se-conjugates

J. Venhorst, M. Rooseboom, N.P.E. Vermeulen, J.N.M. Commandeur

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

1. To investigate whether cytochrome P450 (P450) inhibition can contribute to the chemopreventive activity of selenocysteine Se-conjugates (SeCys conjugates), 21 SeCys conjugates were screened for their inhibitory potency towards seven of the most important human P450s. 2. The majority of the SeCys conjugates produced near complete inhibition of CYP1A1 at a concentration of 250μM. The most potent inhibitor, Se-benzyl-L-selenocysteine, displayed an IC
Original languageEnglish
Pages (from-to)57-72
JournalXenobiotica
Volume33
Issue number1
DOIs
Publication statusPublished - 2003

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