Studies on the inhibition of human cytochromes P450 by selenocysteine Se-conjugates

J. Venhorst; M. Rooseboom; N.P.E. Vermeulen; J.N.M. Commandeur

doi:10.1080/0049825021000022357

Studies on the inhibition of human cytochromes P450 by selenocysteine Se-conjugates

J. Venhorst, M. Rooseboom, N.P.E. Vermeulen, J.N.M. Commandeur

Molecular and Computational Toxicology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

1. To investigate whether cytochrome P450 (P450) inhibition can contribute to the chemopreventive activity of selenocysteine Se-conjugates (SeCys conjugates), 21 SeCys conjugates were screened for their inhibitory potency towards seven of the most important human P450s. 2. The majority of the SeCys conjugates produced near complete inhibition of CYP1A1 at a concentration of 250μM. The most potent inhibitor, Se-benzyl-L-selenocysteine, displayed an IC

Original language	English
Pages (from-to)	57-72
Journal	Xenobiotica
Volume	33
Issue number	1
DOIs	https://doi.org/10.1080/0049825021000022357
Publication status	Published - 2003

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abstract = "1. To investigate whether cytochrome P450 (P450) inhibition can contribute to the chemopreventive activity of selenocysteine Se-conjugates (SeCys conjugates), 21 SeCys conjugates were screened for their inhibitory potency towards seven of the most important human P450s. 2. The majority of the SeCys conjugates produced near complete inhibition of CYP1A1 at a concentration of 250μM. The most potent inhibitor, Se-benzyl-L-selenocysteine, displayed an IC",

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AU - Vermeulen, N.P.E.

AU - Commandeur, J.N.M.

PY - 2003

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AB - 1. To investigate whether cytochrome P450 (P450) inhibition can contribute to the chemopreventive activity of selenocysteine Se-conjugates (SeCys conjugates), 21 SeCys conjugates were screened for their inhibitory potency towards seven of the most important human P450s. 2. The majority of the SeCys conjugates produced near complete inhibition of CYP1A1 at a concentration of 250μM. The most potent inhibitor, Se-benzyl-L-selenocysteine, displayed an IC

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DO - 10.1080/0049825021000022357

M3 - Article

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JO - Xenobiotica

JF - Xenobiotica

SN - 0049-8254

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ER -

Studies on the inhibition of human cytochromes P450 by selenocysteine Se-conjugates

Abstract

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