TY - JOUR
T1 - Studies on the inhibition of human cytochromes P450 by selenocysteine Se-conjugates
AU - Venhorst, J.
AU - Rooseboom, M.
AU - Vermeulen, N.P.E.
AU - Commandeur, J.N.M.
PY - 2003
Y1 - 2003
N2 - 1. To investigate whether cytochrome P450 (P450) inhibition can contribute to the chemopreventive activity of selenocysteine Se-conjugates (SeCys conjugates), 21 SeCys conjugates were screened for their inhibitory potency towards seven of the most important human P450s. 2. The majority of the SeCys conjugates produced near complete inhibition of CYP1A1 at a concentration of 250μM. The most potent inhibitor, Se-benzyl-L-selenocysteine, displayed an IC
AB - 1. To investigate whether cytochrome P450 (P450) inhibition can contribute to the chemopreventive activity of selenocysteine Se-conjugates (SeCys conjugates), 21 SeCys conjugates were screened for their inhibitory potency towards seven of the most important human P450s. 2. The majority of the SeCys conjugates produced near complete inhibition of CYP1A1 at a concentration of 250μM. The most potent inhibitor, Se-benzyl-L-selenocysteine, displayed an IC
UR - https://www.scopus.com/pages/publications/0037232813
UR - https://www.scopus.com/inward/citedby.url?scp=0037232813&partnerID=8YFLogxK
U2 - 10.1080/0049825021000022357
DO - 10.1080/0049825021000022357
M3 - Article
SN - 0049-8254
VL - 33
SP - 57
EP - 72
JO - Xenobiotica
JF - Xenobiotica
IS - 1
ER -
