Subcellular imaging mass spectrometry of brain tissue

J. Mcdonnell; S.R. Piersma; A.F.M. Altelaar; T.H. Mize; S.L. Luxembourg; P.D.E.M. Verhaert; J. van Minnen; R.M.A. Heeren

doi:10.1002/jms.735

Subcellular imaging mass spectrometry of brain tissue

J. Mcdonnell, S.R. Piersma, A.F.M. Altelaar, T.H. Mize, S.L. Luxembourg, P.D.E.M. Verhaert, J. van Minnen, R.M.A. Heeren

Molecular and Cellular Neurobiology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Imaging mass spectrometry provides both chemical information and the spatial distribution of each analyte detected. Here it is demonstrated how imaging mass spectrometry of tissue at subcellular resolution can be achieved by combining the high spatial resolution of secondary ion mass spectrometry (SIMS) with the sample preparation protocols of matrix-assisted laser desorption/ionization (MALDI). Despite mechanistic differences and sampling 10

Original language	English
Pages (from-to)	160-168
Number of pages	9
Journal	Journal of Mass Spectrometry
Volume	40
Issue number	2
DOIs	https://doi.org/10.1002/jms.735
Publication status	Published - 2005

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10.1002/jms.735

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title = "Subcellular imaging mass spectrometry of brain tissue",

abstract = "Imaging mass spectrometry provides both chemical information and the spatial distribution of each analyte detected. Here it is demonstrated how imaging mass spectrometry of tissue at subcellular resolution can be achieved by combining the high spatial resolution of secondary ion mass spectrometry (SIMS) with the sample preparation protocols of matrix-assisted laser desorption/ionization (MALDI). Despite mechanistic differences and sampling 10",

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AU - Mcdonnell, J.

AU - Piersma, S.R.

AU - Altelaar, A.F.M.

AU - Mize, T.H.

AU - Luxembourg, S.L.

AU - Verhaert, P.D.E.M.

AU - van Minnen, J.

AU - Heeren, R.M.A.

PY - 2005

Y1 - 2005

N2 - Imaging mass spectrometry provides both chemical information and the spatial distribution of each analyte detected. Here it is demonstrated how imaging mass spectrometry of tissue at subcellular resolution can be achieved by combining the high spatial resolution of secondary ion mass spectrometry (SIMS) with the sample preparation protocols of matrix-assisted laser desorption/ionization (MALDI). Despite mechanistic differences and sampling 10

AB - Imaging mass spectrometry provides both chemical information and the spatial distribution of each analyte detected. Here it is demonstrated how imaging mass spectrometry of tissue at subcellular resolution can be achieved by combining the high spatial resolution of secondary ion mass spectrometry (SIMS) with the sample preparation protocols of matrix-assisted laser desorption/ionization (MALDI). Despite mechanistic differences and sampling 10

U2 - 10.1002/jms.735

DO - 10.1002/jms.735

M3 - Article

SN - 1076-5174

VL - 40

SP - 160

EP - 168

JO - Journal of Mass Spectrometry

JF - Journal of Mass Spectrometry

IS - 2

ER -

Subcellular imaging mass spectrometry of brain tissue

Abstract

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