Subcellular imaging mass spectrometry of brain tissue

J. Mcdonnell, S.R. Piersma, A.F.M. Altelaar, T.H. Mize, S.L. Luxembourg, P.D.E.M. Verhaert, J. van Minnen, R.M.A. Heeren

Research output: Contribution to JournalArticleAcademicpeer-review


Imaging mass spectrometry provides both chemical information and the spatial distribution of each analyte detected. Here it is demonstrated how imaging mass spectrometry of tissue at subcellular resolution can be achieved by combining the high spatial resolution of secondary ion mass spectrometry (SIMS) with the sample preparation protocols of matrix-assisted laser desorption/ionization (MALDI). Despite mechanistic differences and sampling 10
Original languageEnglish
Pages (from-to)160-168
Number of pages9
JournalJournal of Mass Spectrometry
Issue number2
Publication statusPublished - 2005


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