Substance use: Interplay between polygenic risk and neighborhood environment

Joëlle A Pasman; Karin J H Verweij; Abdel Abdellaoui; Jouke Jan Hottenga; Iryna O Fedko; Gonneke Willemsen; Dorret I Boomsma; Jacqueline M Vink

doi:10.1016/j.drugalcdep.2020.107948

Substance use: Interplay between polygenic risk and neighborhood environment

Joëlle A Pasman
, Karin J H Verweij
, Abdel Abdellaoui
, Jouke Jan Hottenga
, Iryna O Fedko
, Gonneke Willemsen
, Dorret I Boomsma
, Jacqueline M Vink

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

BACKGROUND: Tobacco, alcohol, and cannabis use are prevalent behaviors that pose considerable health risks. Genetic vulnerability and characteristics of the neighborhood of residence form important risk factors for substance use. Possibly, these factors do not act in isolation. This study tested the interaction between neighborhood characteristics and genetic risk (gene-environment interaction, GxE) and the association between these classes of risk factors (gene-environment correlation, rGE) in substance use.

METHODS: Two polygenic scores (PGS) each (based on different discovery datasets) were created for smoking initiation, cigarettes per day, and glasses of alcohol per week based on summary statistics of different genome-wide association studies (GWAS). For cannabis initiation one PGS was created. These PGS were used to predict their respective phenotype in a large population-based sample from the Netherlands Twin Register (N = 6,567). Neighborhood characteristics as retrieved from governmental registration systems were factor analyzed and resulting measures of socioeconomic status (SES) and metropolitanism were used as predictors.

RESULTS: There were (small) main effects of neighborhood characteristics and PGS on substance use. One of the 14 tested GxE effects was significant, such that the PGS was more strongly associated with alcohol use in individuals with high SES. This was effect was only significant for one out of two PGS. There were weak indications of rGE, mainly with age and cohort covariates.

CONCLUSION: We conclude that both genetic and neighborhood-level factors are predictors for substance use. More research is needed to establish the robustness of the findings on the interplay between these factors.

Original language	English
Article number	107948
Pages (from-to)	1-8
Number of pages	8
Journal	Drug and Alcohol Dependence
Volume	209
Early online date	28 Feb 2020
DOIs	https://doi.org/10.1016/j.drugalcdep.2020.107948
Publication status	Published - 1 Apr 2020

Bibliographical note

Funding

Funders	Funder number
Avera Institute
BBMRI
BiG Grid	480‐05‐003, 284167
Biobanking and Biomolecular Resources Research Infrastructure
Center for Medical Systems Biology
ENGAGE	HEALTH-F4-2007-201413
European Community's Seventh Framework Program	FP7/2007-2013
European Science Council
Foundation Volksbond Rotterdam
NBIC/BioAssist/RK	2008.024, 184.021.007
Netherlands Organization for Scientific Research
Spinozapremie	56-464-14192
National Institutes of Health	1RC2 MH089951, MH081802, 1RC2 MH08999, R01D0042157-01A
National Institute of Mental Health	U24 MH068457-06
National Institute on Drug Abuse	R01DA042157
College of Environmental Science and Forestry, State University of New York	EU/QLRT-2001-01254
European Research Council	230374
European Science Foundation
ZonMw	849200011
Nederlandse Organisatie voor Wetenschappelijk Onderzoek	480-04-004, 463-06-001, 904-61-090, 400-05-717, 451-04-034, 904-61-193, 985-10-002, 912-10-020
Leids Universitair Medisch Centrum
Universitair Medisch Centrum Groningen

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Cohort Studies

Netherlands Twin Register (NTR)

Access to Document

10.1016/j.drugalcdep.2020.107948

Persistent URL (handle)

Persistent link

Cite this

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title = "Substance use: Interplay between polygenic risk and neighborhood environment",

abstract = "BACKGROUND: Tobacco, alcohol, and cannabis use are prevalent behaviors that pose considerable health risks. Genetic vulnerability and characteristics of the neighborhood of residence form important risk factors for substance use. Possibly, these factors do not act in isolation. This study tested the interaction between neighborhood characteristics and genetic risk (gene-environment interaction, GxE) and the association between these classes of risk factors (gene-environment correlation, rGE) in substance use.METHODS: Two polygenic scores (PGS) each (based on different discovery datasets) were created for smoking initiation, cigarettes per day, and glasses of alcohol per week based on summary statistics of different genome-wide association studies (GWAS). For cannabis initiation one PGS was created. These PGS were used to predict their respective phenotype in a large population-based sample from the Netherlands Twin Register (N = 6,567). Neighborhood characteristics as retrieved from governmental registration systems were factor analyzed and resulting measures of socioeconomic status (SES) and metropolitanism were used as predictors.RESULTS: There were (small) main effects of neighborhood characteristics and PGS on substance use. One of the 14 tested GxE effects was significant, such that the PGS was more strongly associated with alcohol use in individuals with high SES. This was effect was only significant for one out of two PGS. There were weak indications of rGE, mainly with age and cohort covariates.CONCLUSION: We conclude that both genetic and neighborhood-level factors are predictors for substance use. More research is needed to establish the robustness of the findings on the interplay between these factors.",

author = "Pasman, \{Jo{\"e}lle A\} and Verweij, \{Karin J H\} and Abdel Abdellaoui and Hottenga, \{Jouke Jan\} and Fedko, \{Iryna O\} and Gonneke Willemsen and Boomsma, \{Dorret I\} and Vink, \{Jacqueline M\}",

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AU - Pasman, Joëlle A

AU - Verweij, Karin J H

AU - Abdellaoui, Abdel

AU - Hottenga, Jouke Jan

AU - Fedko, Iryna O

AU - Willemsen, Gonneke

AU - Boomsma, Dorret I

AU - Vink, Jacqueline M

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N2 - BACKGROUND: Tobacco, alcohol, and cannabis use are prevalent behaviors that pose considerable health risks. Genetic vulnerability and characteristics of the neighborhood of residence form important risk factors for substance use. Possibly, these factors do not act in isolation. This study tested the interaction between neighborhood characteristics and genetic risk (gene-environment interaction, GxE) and the association between these classes of risk factors (gene-environment correlation, rGE) in substance use.METHODS: Two polygenic scores (PGS) each (based on different discovery datasets) were created for smoking initiation, cigarettes per day, and glasses of alcohol per week based on summary statistics of different genome-wide association studies (GWAS). For cannabis initiation one PGS was created. These PGS were used to predict their respective phenotype in a large population-based sample from the Netherlands Twin Register (N = 6,567). Neighborhood characteristics as retrieved from governmental registration systems were factor analyzed and resulting measures of socioeconomic status (SES) and metropolitanism were used as predictors.RESULTS: There were (small) main effects of neighborhood characteristics and PGS on substance use. One of the 14 tested GxE effects was significant, such that the PGS was more strongly associated with alcohol use in individuals with high SES. This was effect was only significant for one out of two PGS. There were weak indications of rGE, mainly with age and cohort covariates.CONCLUSION: We conclude that both genetic and neighborhood-level factors are predictors for substance use. More research is needed to establish the robustness of the findings on the interplay between these factors.

AB - BACKGROUND: Tobacco, alcohol, and cannabis use are prevalent behaviors that pose considerable health risks. Genetic vulnerability and characteristics of the neighborhood of residence form important risk factors for substance use. Possibly, these factors do not act in isolation. This study tested the interaction between neighborhood characteristics and genetic risk (gene-environment interaction, GxE) and the association between these classes of risk factors (gene-environment correlation, rGE) in substance use.METHODS: Two polygenic scores (PGS) each (based on different discovery datasets) were created for smoking initiation, cigarettes per day, and glasses of alcohol per week based on summary statistics of different genome-wide association studies (GWAS). For cannabis initiation one PGS was created. These PGS were used to predict their respective phenotype in a large population-based sample from the Netherlands Twin Register (N = 6,567). Neighborhood characteristics as retrieved from governmental registration systems were factor analyzed and resulting measures of socioeconomic status (SES) and metropolitanism were used as predictors.RESULTS: There were (small) main effects of neighborhood characteristics and PGS on substance use. One of the 14 tested GxE effects was significant, such that the PGS was more strongly associated with alcohol use in individuals with high SES. This was effect was only significant for one out of two PGS. There were weak indications of rGE, mainly with age and cohort covariates.CONCLUSION: We conclude that both genetic and neighborhood-level factors are predictors for substance use. More research is needed to establish the robustness of the findings on the interplay between these factors.

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Substance use: Interplay between polygenic risk and neighborhood environment

Abstract

Bibliographical note

Funding

UN SDGs

Cohort Studies

Access to Document

Persistent URL (handle)

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Cite this