Surface Plasmon Resonance biosensor analysis as a useful tool in FBDD

K. Retra, H. Irth, J.E. van Muijlwijk- Koezen

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

SPR (Surface Plasmon Resonance) biosensor instruments are more and more equipped to sensitively measure the binding characteristics of small molecules to their target. Via SPR biosensor measurements, not only the affinity of compounds but also other features such as the kinetics and thermodynamics aspects of binding can be determined. Furthermore, SPR is able to determine nonideal behavior of the fragment, such as aggregation and poor solubility binding. The use of SPR biosensors in various phases of the drug discovery process is evaluated. © 2010 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)e181-e187
Number of pages7
JournalDrug Discovery Today: Technologies
Volume7
Issue number3
DOIs
Publication statusPublished - Oct 2010

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Surface Plasmon Resonance
Biosensing Techniques
Drug Discovery
Thermodynamics
Solubility

Bibliographical note

Available online 14 December 2010

Cite this

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author = "K. Retra and H. Irth and {van Muijlwijk- Koezen}, J.E.",
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Surface Plasmon Resonance biosensor analysis as a useful tool in FBDD. / Retra, K.; Irth, H.; van Muijlwijk- Koezen, J.E.

In: Drug Discovery Today: Technologies, Vol. 7, No. 3, 10.2010, p. e181-e187.

Research output: Contribution to JournalArticleAcademicpeer-review

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T1 - Surface Plasmon Resonance biosensor analysis as a useful tool in FBDD

AU - Retra, K.

AU - Irth, H.

AU - van Muijlwijk- Koezen, J.E.

N1 - Available online 14 December 2010

PY - 2010/10

Y1 - 2010/10

N2 - SPR (Surface Plasmon Resonance) biosensor instruments are more and more equipped to sensitively measure the binding characteristics of small molecules to their target. Via SPR biosensor measurements, not only the affinity of compounds but also other features such as the kinetics and thermodynamics aspects of binding can be determined. Furthermore, SPR is able to determine nonideal behavior of the fragment, such as aggregation and poor solubility binding. The use of SPR biosensors in various phases of the drug discovery process is evaluated. © 2010 Elsevier Ltd. All rights reserved.

AB - SPR (Surface Plasmon Resonance) biosensor instruments are more and more equipped to sensitively measure the binding characteristics of small molecules to their target. Via SPR biosensor measurements, not only the affinity of compounds but also other features such as the kinetics and thermodynamics aspects of binding can be determined. Furthermore, SPR is able to determine nonideal behavior of the fragment, such as aggregation and poor solubility binding. The use of SPR biosensors in various phases of the drug discovery process is evaluated. © 2010 Elsevier Ltd. All rights reserved.

U2 - 10.1016/j.ddtec.2010.11.012

DO - 10.1016/j.ddtec.2010.11.012

M3 - Article

VL - 7

SP - e181-e187

JO - Drug Discovery Today: Technologies

JF - Drug Discovery Today: Technologies

SN - 1740-6749

IS - 3

ER -