Surface Plasmon Resonance Biosensor Based Fragment Screening Using Acetylcholine Binding Protein Identifies Ligand Efficiency Hot Spots (LE Hot Spots) by Deconstruction of Nicotinic Acetylcholine Receptor α7 Ligands

G.E. de Kloe, K. Retra, M. Geitmann, B. Kallblad, T.T. Nahar, R. van Elk, A.B. Smit, J.E. van Muijlwijk- Koezen, R. Leurs, H. Irth, U.H. Danielson, I.J.P. de Esch

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Medicine & Life Sciences