Symptom dimensions in OCD: item-level factor analysis and heritability estimates

H. Katerberg; K.L. Delucchi; S.E. Stewart; C. Lochner; D.A.J.P. Denys; D.E. Stack; J.M. Andresen; J.E. Grant; S.W. Kim; K.A. Williams; J.A. den Boer; A.J.L.M. van Balkom; J.H. Smit; P.C. van Oppen; A. Polman; M.A. Jenike; D.J. Stein; C.A. Mathews; D.C. Cath

doi:10.1007/s10519-010-9339-z

Symptom dimensions in OCD: item-level factor analysis and heritability estimates

H. Katerberg, K.L. Delucchi, S.E. Stewart, C. Lochner, D.A.J.P. Denys, D.E. Stack, J.M. Andresen, J.E. Grant, S.W. Kim, K.A. Williams, J.A. den Boer, A.J.L.M. van Balkom, J.H. Smit, P.C. van Oppen, A. Polman, M.A. Jenike, D.J. Stein, C.A. Mathews, D.C. Cath

Research output: Contribution to Journal › Article › Academic › peer-review

164 Downloads (Pure)

Abstract

To reduce the phenotypic heterogeneity of obsessive-compulsive disorder (OCD) for genetic, clinical and translational studies, numerous factor analyses of the Yale-Brown Obsessive Compulsive Scale checklist (YBOCS-CL) have been conducted. Results of these analyses have been inconsistent, likely as a consequence of small sample sizes and variable methodologies. Furthermore, data concerning the heritability of the factors are limited. Item and category-level factor analyses of YBOCS-CL items from 1224 OCD subjects were followed by heritability analyses in 52 OCD-affected multigenerational families. Item-level analyses indicated that a five factor model: (1) taboo, (2) contamination/ cleaning, (3) doubts, (4) superstitions/rituals, and (5) symmetry/hoarding provided the best fit, followed by a one-factor solution. All 5 factors as well as the one-factor solution were found to be heritable. Bivariate analyses indicated that the taboo and doubts factor, and the contamination and symmetry/ hoarding factor share genetic influences. Contamination and symmetry/hoarding show shared genetic variance with symptom severity. Nearly all factors showed shared environmental variance with each other and with symptom severity. These results support the utility of both OCD diagnosis and symptom dimensions in genetic research and clinical contexts. Both shared and unique genetic influences underlie susceptibility to OCD and its symptom dimensions. © The Author(s) 2010.

Original language	English
Pages (from-to)	505-517
Journal	Behavior Genetics
Volume	40
Issue number	4
DOIs	https://doi.org/10.1007/s10519-010-9339-z
Publication status	Published - 2010

Access to Document

10.1007/s10519-010-9339-z

256862Final published version, 222 KB

Fingerprint Dive into the research topics of 'Symptom dimensions in OCD: item-level factor analysis and heritability estimates'. Together they form a unique fingerprint.

Cite this

Katerberg, H., Delucchi, K. L., Stewart, S. E., Lochner, C., Denys, D. A. J. P., Stack, D. E., Andresen, J. M., Grant, J. E., Kim, S. W., Williams, K. A., den Boer, J. A., van Balkom, A. J. L. M., Smit, J. H., van Oppen, P. C., Polman, A., Jenike, M. A., Stein, D. J., Mathews, C. A., & Cath, D. C. (2010). Symptom dimensions in OCD: item-level factor analysis and heritability estimates. Behavior Genetics, 40(4), 505-517. https://doi.org/10.1007/s10519-010-9339-z

Katerberg, H. ; Delucchi, K.L. ; Stewart, S.E. ; Lochner, C. ; Denys, D.A.J.P. ; Stack, D.E. ; Andresen, J.M. ; Grant, J.E. ; Kim, S.W. ; Williams, K.A. ; den Boer, J.A. ; van Balkom, A.J.L.M. ; Smit, J.H. ; van Oppen, P.C. ; Polman, A. ; Jenike, M.A. ; Stein, D.J. ; Mathews, C.A. ; Cath, D.C. / Symptom dimensions in OCD: item-level factor analysis and heritability estimates. In: Behavior Genetics. 2010 ; Vol. 40, No. 4. pp. 505-517.

@article{8c230c1275be48e1829ec4d8a4069123,

title = "Symptom dimensions in OCD: item-level factor analysis and heritability estimates",

abstract = "To reduce the phenotypic heterogeneity of obsessive-compulsive disorder (OCD) for genetic, clinical and translational studies, numerous factor analyses of the Yale-Brown Obsessive Compulsive Scale checklist (YBOCS-CL) have been conducted. Results of these analyses have been inconsistent, likely as a consequence of small sample sizes and variable methodologies. Furthermore, data concerning the heritability of the factors are limited. Item and category-level factor analyses of YBOCS-CL items from 1224 OCD subjects were followed by heritability analyses in 52 OCD-affected multigenerational families. Item-level analyses indicated that a five factor model: (1) taboo, (2) contamination/ cleaning, (3) doubts, (4) superstitions/rituals, and (5) symmetry/hoarding provided the best fit, followed by a one-factor solution. All 5 factors as well as the one-factor solution were found to be heritable. Bivariate analyses indicated that the taboo and doubts factor, and the contamination and symmetry/ hoarding factor share genetic influences. Contamination and symmetry/hoarding show shared genetic variance with symptom severity. Nearly all factors showed shared environmental variance with each other and with symptom severity. These results support the utility of both OCD diagnosis and symptom dimensions in genetic research and clinical contexts. Both shared and unique genetic influences underlie susceptibility to OCD and its symptom dimensions. {\textcopyright} The Author(s) 2010.",

author = "H. Katerberg and K.L. Delucchi and S.E. Stewart and C. Lochner and D.A.J.P. Denys and D.E. Stack and J.M. Andresen and J.E. Grant and S.W. Kim and K.A. Williams and {den Boer}, J.A. and {van Balkom}, A.J.L.M. and J.H. Smit and {van Oppen}, P.C. and A. Polman and M.A. Jenike and D.J. Stein and C.A. Mathews and D.C. Cath",

year = "2010",

doi = "10.1007/s10519-010-9339-z",

language = "English",

volume = "40",

pages = "505--517",

journal = "Behavior Genetics",

issn = "0001-8244",

publisher = "Springer",

number = "4",

}

Katerberg, H, Delucchi, KL, Stewart, SE, Lochner, C, Denys, DAJP, Stack, DE, Andresen, JM, Grant, JE, Kim, SW, Williams, KA, den Boer, JA, van Balkom, AJLM, Smit, JH, van Oppen, PC, Polman, A, Jenike, MA, Stein, DJ, Mathews, CA & Cath, DC 2010, 'Symptom dimensions in OCD: item-level factor analysis and heritability estimates', Behavior Genetics, vol. 40, no. 4, pp. 505-517. https://doi.org/10.1007/s10519-010-9339-z

Symptom dimensions in OCD: item-level factor analysis and heritability estimates. / Katerberg, H.; Delucchi, K.L.; Stewart, S.E.; Lochner, C.; Denys, D.A.J.P.; Stack, D.E.; Andresen, J.M.; Grant, J.E.; Kim, S.W.; Williams, K.A.; den Boer, J.A.; van Balkom, A.J.L.M.; Smit, J.H.; van Oppen, P.C.; Polman, A.; Jenike, M.A.; Stein, D.J.; Mathews, C.A.; Cath, D.C.

In: Behavior Genetics, Vol. 40, No. 4, 2010, p. 505-517.

Research output: Contribution to Journal › Article › Academic › peer-review

TY - JOUR

T1 - Symptom dimensions in OCD: item-level factor analysis and heritability estimates

AU - Katerberg, H.

AU - Delucchi, K.L.

AU - Stewart, S.E.

AU - Lochner, C.

AU - Denys, D.A.J.P.

AU - Stack, D.E.

AU - Andresen, J.M.

AU - Grant, J.E.

AU - Kim, S.W.

AU - Williams, K.A.

AU - den Boer, J.A.

AU - van Balkom, A.J.L.M.

AU - Smit, J.H.

AU - van Oppen, P.C.

AU - Polman, A.

AU - Jenike, M.A.

AU - Stein, D.J.

AU - Mathews, C.A.

AU - Cath, D.C.

PY - 2010

Y1 - 2010

N2 - To reduce the phenotypic heterogeneity of obsessive-compulsive disorder (OCD) for genetic, clinical and translational studies, numerous factor analyses of the Yale-Brown Obsessive Compulsive Scale checklist (YBOCS-CL) have been conducted. Results of these analyses have been inconsistent, likely as a consequence of small sample sizes and variable methodologies. Furthermore, data concerning the heritability of the factors are limited. Item and category-level factor analyses of YBOCS-CL items from 1224 OCD subjects were followed by heritability analyses in 52 OCD-affected multigenerational families. Item-level analyses indicated that a five factor model: (1) taboo, (2) contamination/ cleaning, (3) doubts, (4) superstitions/rituals, and (5) symmetry/hoarding provided the best fit, followed by a one-factor solution. All 5 factors as well as the one-factor solution were found to be heritable. Bivariate analyses indicated that the taboo and doubts factor, and the contamination and symmetry/ hoarding factor share genetic influences. Contamination and symmetry/hoarding show shared genetic variance with symptom severity. Nearly all factors showed shared environmental variance with each other and with symptom severity. These results support the utility of both OCD diagnosis and symptom dimensions in genetic research and clinical contexts. Both shared and unique genetic influences underlie susceptibility to OCD and its symptom dimensions. © The Author(s) 2010.

AB - To reduce the phenotypic heterogeneity of obsessive-compulsive disorder (OCD) for genetic, clinical and translational studies, numerous factor analyses of the Yale-Brown Obsessive Compulsive Scale checklist (YBOCS-CL) have been conducted. Results of these analyses have been inconsistent, likely as a consequence of small sample sizes and variable methodologies. Furthermore, data concerning the heritability of the factors are limited. Item and category-level factor analyses of YBOCS-CL items from 1224 OCD subjects were followed by heritability analyses in 52 OCD-affected multigenerational families. Item-level analyses indicated that a five factor model: (1) taboo, (2) contamination/ cleaning, (3) doubts, (4) superstitions/rituals, and (5) symmetry/hoarding provided the best fit, followed by a one-factor solution. All 5 factors as well as the one-factor solution were found to be heritable. Bivariate analyses indicated that the taboo and doubts factor, and the contamination and symmetry/ hoarding factor share genetic influences. Contamination and symmetry/hoarding show shared genetic variance with symptom severity. Nearly all factors showed shared environmental variance with each other and with symptom severity. These results support the utility of both OCD diagnosis and symptom dimensions in genetic research and clinical contexts. Both shared and unique genetic influences underlie susceptibility to OCD and its symptom dimensions. © The Author(s) 2010.

U2 - 10.1007/s10519-010-9339-z

DO - 10.1007/s10519-010-9339-z

M3 - Article

VL - 40

SP - 505

EP - 517

JO - Behavior Genetics

JF - Behavior Genetics

SN - 0001-8244

IS - 4

ER -