Synaptic plasticity in human cortical circuits: cellular mechanisms of learning and memory in the human brain?

Huibert D. Mansvelder; Matthijs B. Verhoog; Natalia A. Goriounova

doi:10.1016/j.conb.2018.06.013

Synaptic plasticity in human cortical circuits: cellular mechanisms of learning and memory in the human brain?

Huibert D. Mansvelder, Matthijs B. Verhoog, Natalia A. Goriounova

Research output: Contribution to Journal › Review article › Academic › peer-review

Abstract

Synaptic plasticity is the cellular basis of learning and memory, but to what extent this holds for the adult human brain is not known. To study synaptic plasticity in human neuronal circuits poses a huge challenge, since live human neurons and synapses are not readily accessible. Despite this, various lines of research have provided insights in properties of adult human synapses and their plasticity both in vitro and in vivo, with some unexpected surprises. We first discuss the experimental approaches to study activity-dependent plasticity of adult human synapses, and then highlight rules and mechanisms of Hebbian spike timing-dependent plasticity (STDP) found in these synapses. Finally, we conclude with thoughts on how these synaptic principles can underlie human learning and memory.

Original language	English
Pages (from-to)	186-193
Number of pages	8
Journal	Current Opinion in Neurobiology
Volume	54
Early online date	13 Jul 2018
DOIs	https://doi.org/10.1016/j.conb.2018.06.013
Publication status	Published - Feb 2019

Funding

HDM received funding for this work from the Netherlands Organization for Scientific Research (NWO; VICI grant), ERC StG `BrainSignals’, EU H2020 (agreement no. 604102 `Human Brain Project’). MBV received funding for this work from a University of Cape Town Faculty of Health Sciences Postdoctoral Fellowship. NAG received funding from the Netherlands Organization for Scientific Research (NWO; VENI grant).

Funders	Funder number
EU H2020
Netherlands Organization for Scientific Research
Horizon 2020 Framework Programme	604102
European Research Council
Nederlandse Organisatie voor Wetenschappelijk Onderzoek
Erzincan Üniversitesi

Access to Document

10.1016/j.conb.2018.06.013

Persistent URL (handle)

Persistent link

Cite this

@article{c3d286d9aef743afae81ef8bbd6822b5,

title = "Synaptic plasticity in human cortical circuits: cellular mechanisms of learning and memory in the human brain?",

abstract = "Synaptic plasticity is the cellular basis of learning and memory, but to what extent this holds for the adult human brain is not known. To study synaptic plasticity in human neuronal circuits poses a huge challenge, since live human neurons and synapses are not readily accessible. Despite this, various lines of research have provided insights in properties of adult human synapses and their plasticity both in vitro and in vivo, with some unexpected surprises. We first discuss the experimental approaches to study activity-dependent plasticity of adult human synapses, and then highlight rules and mechanisms of Hebbian spike timing-dependent plasticity (STDP) found in these synapses. Finally, we conclude with thoughts on how these synaptic principles can underlie human learning and memory.",

author = "Mansvelder, {Huibert D.} and Verhoog, {Matthijs B.} and Goriounova, {Natalia A.}",

year = "2019",

month = feb,

doi = "10.1016/j.conb.2018.06.013",

language = "English",

volume = "54",

pages = "186--193",

journal = "Current Opinion in Neurobiology",

issn = "0959-4388",

publisher = "Elsevier Ltd",

}

TY - JOUR

T1 - Synaptic plasticity in human cortical circuits

T2 - cellular mechanisms of learning and memory in the human brain?

AU - Mansvelder, Huibert D.

AU - Verhoog, Matthijs B.

AU - Goriounova, Natalia A.

PY - 2019/2

Y1 - 2019/2

N2 - Synaptic plasticity is the cellular basis of learning and memory, but to what extent this holds for the adult human brain is not known. To study synaptic plasticity in human neuronal circuits poses a huge challenge, since live human neurons and synapses are not readily accessible. Despite this, various lines of research have provided insights in properties of adult human synapses and their plasticity both in vitro and in vivo, with some unexpected surprises. We first discuss the experimental approaches to study activity-dependent plasticity of adult human synapses, and then highlight rules and mechanisms of Hebbian spike timing-dependent plasticity (STDP) found in these synapses. Finally, we conclude with thoughts on how these synaptic principles can underlie human learning and memory.

AB - Synaptic plasticity is the cellular basis of learning and memory, but to what extent this holds for the adult human brain is not known. To study synaptic plasticity in human neuronal circuits poses a huge challenge, since live human neurons and synapses are not readily accessible. Despite this, various lines of research have provided insights in properties of adult human synapses and their plasticity both in vitro and in vivo, with some unexpected surprises. We first discuss the experimental approaches to study activity-dependent plasticity of adult human synapses, and then highlight rules and mechanisms of Hebbian spike timing-dependent plasticity (STDP) found in these synapses. Finally, we conclude with thoughts on how these synaptic principles can underlie human learning and memory.

UR - http://www.scopus.com/inward/record.url?scp=85049735134&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85049735134&partnerID=8YFLogxK

U2 - 10.1016/j.conb.2018.06.013

DO - 10.1016/j.conb.2018.06.013

M3 - Review article

C2 - 30017789

AN - SCOPUS:85049735134

SN - 0959-4388

VL - 54

SP - 186

EP - 193

JO - Current Opinion in Neurobiology

JF - Current Opinion in Neurobiology

ER -

Synaptic plasticity in human cortical circuits: cellular mechanisms of learning and memory in the human brain?

Abstract

Funding

Access to Document

Persistent URL (handle)

Other files and links

Fingerprint

Cite this