Synthesis and initial preclinical evaluation of the P2X(7) receptor antagonist [C-11]A-740003 as a novel tracer of neuroinflammation

B. Janssen; D.J. Vugts; U. Funke; A. Spaans; R.C. Schuit; E. Kooijman; M. Rongen; L.R. Perk; A.A. Lammertsma; A.D. Windhorst

doi:10.1002/jlcr.3206

Synthesis and initial preclinical evaluation of the P2X(7) receptor antagonist [C-11]A-740003 as a novel tracer of neuroinflammation

B. Janssen
, D.J. Vugts
, U. Funke
, A. Spaans
, R.C. Schuit
, E. Kooijman
, M. Rongen
, L.R. Perk
, A.A. Lammertsma
, A.D. Windhorst

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Neuroinflammation, in particular activation of microglia, is thought to play an important role in the progression of neurodegenerative diseases. In activated microglia, the purinergic P2X

Original language	English
Pages (from-to)	509-516
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	57
Issue number	8
DOIs	https://doi.org/10.1002/jlcr.3206
Publication status	Published - 2014

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SDG 3 Good Health and Well-being

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10.1002/jlcr.3206

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Janssen, B., Vugts, D. J., Funke, U., Spaans, A., Schuit, R. C., Kooijman, E., Rongen, M., Perk, L. R., Lammertsma, A. A., & Windhorst, A. D. (2014). Synthesis and initial preclinical evaluation of the P2X(7) receptor antagonist [C-11]A-740003 as a novel tracer of neuroinflammation. Journal of Labelled Compounds and Radiopharmaceuticals, 57(8), 509-516. https://doi.org/10.1002/jlcr.3206

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title = "Synthesis and initial preclinical evaluation of the P2X(7) receptor antagonist [C-11]A-740003 as a novel tracer of neuroinflammation",

abstract = "Neuroinflammation, in particular activation of microglia, is thought to play an important role in the progression of neurodegenerative diseases. In activated microglia, the purinergic P2X",

author = "B. Janssen and D.J. Vugts and U. Funke and A. Spaans and R.C. Schuit and E. Kooijman and M. Rongen and L.R. Perk and A.A. Lammertsma and A.D. Windhorst",

year = "2014",

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Janssen, B, Vugts, DJ, Funke, U, Spaans, A, Schuit, RC, Kooijman, E, Rongen, M, Perk, LR, Lammertsma, AA & Windhorst, AD 2014, 'Synthesis and initial preclinical evaluation of the P2X(7) receptor antagonist [C-11]A-740003 as a novel tracer of neuroinflammation', Journal of Labelled Compounds and Radiopharmaceuticals, vol. 57, no. 8, pp. 509-516. https://doi.org/10.1002/jlcr.3206

TY - JOUR

T1 - Synthesis and initial preclinical evaluation of the P2X(7) receptor antagonist [C-11]A-740003 as a novel tracer of neuroinflammation

AU - Janssen, B.

AU - Vugts, D.J.

AU - Funke, U.

AU - Spaans, A.

AU - Schuit, R.C.

AU - Kooijman, E.

AU - Rongen, M.

AU - Perk, L.R.

AU - Lammertsma, A.A.

AU - Windhorst, A.D.

PY - 2014

Y1 - 2014

N2 - Neuroinflammation, in particular activation of microglia, is thought to play an important role in the progression of neurodegenerative diseases. In activated microglia, the purinergic P2X

AB - Neuroinflammation, in particular activation of microglia, is thought to play an important role in the progression of neurodegenerative diseases. In activated microglia, the purinergic P2X

U2 - 10.1002/jlcr.3206

DO - 10.1002/jlcr.3206

M3 - Article

SN - 0362-4803

VL - 57

SP - 509

EP - 516

JO - Journal of Labelled Compounds and Radiopharmaceuticals

JF - Journal of Labelled Compounds and Radiopharmaceuticals

IS - 8

ER -

Synthesis and initial preclinical evaluation of the P2X(7) receptor antagonist [C-11]A-740003 as a novel tracer of neuroinflammation

Abstract

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