Synthesis and pharmacological evaluation of some amino-acid-containing cyproheptadine derivatives as dual antagonists of histamine H1- and leukotriene D4-receptors.

M.Q. Zhang, A. van de Stolpe, O.P. Zuiderveld, H. Timmerman

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

A novel series of cyproheptadine derivatives, in which an amino acid or a dipeptide moiety was introduced at the piperidine nitrogen, have been synthesized. The amino acid and dipeptide moieties were taken as part of leukotriene D
Original languageEnglish
Pages (from-to)95-102
JournalEuropean Journal of Medicinal Chemistry
Volume32
DOIs
Publication statusPublished - 1997

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