Synthesis of 3'-deoxyribolactones using a hydrolysis-induced lactonization cascade reaction of epoxy cyanohydrins

D.J. Vugts, H. Aktas, K. Al-Mafraji, F.J.J. de Kanter, E. Ruijter, M.B. Groen, R.V.A. Orru

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

The synthesis of 3′-deoxyribolactones was accomplished in a few steps from the commercially available 3-decyn-1-ol in 44% overall yield. The key transformation comprises a one-pot four-reaction hydrolysis-induced lactonization cascade. The strategy was employed to efficiently access optically active 5′-chloro-3′-deoxyribolactones. © Wiley-VCH Verlag GmbH & Co. KGaA, 2008.
Original languageEnglish
Pages (from-to)1336-1339
JournalEuropean Journal of Organic Chemistry
Issue number8
DOIs
Publication statusPublished - 2008

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