Synthesis of 4-aminoquinolines by aerobic oxidative palladium-catalyzed double C-H activation and isocyanide insertion

T. Vlaar, B.U.W. Maes, E. Ruijter, R.V.A. Orru

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

An unprecedented aerobic oxidative Pd-catalyzed imidoylative coupling of two C-H fragments furnishing medicinally valuable 4-aminoquinolines is reported. Optimization studies are described and several analogs were successfully prepared. © 2013 Springer Science+Business Media New York.
Original languageEnglish
Pages (from-to)902-908
JournalChemistry of Heterocyclic Compounds
Volume2013
Issue number49
DOIs
Publication statusPublished - 2013

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