Synthesis of biologically relevant molecules

Matthijs J. van Lint*, Eelco Ruijter, Romano V.A. Orru

*Corresponding author for this work

Research output: Chapter in Book / Report / Conference proceedingChapterAcademicpeer-review


Complex polycyclic molecular scaffolds containing multiple stereocenters, as found in many natural products, present particularly appealing targets for synthetic chemists. In addition to the academic challenge of selectively constructing these intricate frameworks, many such compounds display valuable bioactivities, making them important starting points for drug discovery. As in many aspects of contemporary organic synthesis, catalysis plays a key role in many MBFTs toward biologically relevant molecules (BRMs). Recently developed catalytic methodologies allow novel types of C-C bond formations and/or unprecedented control over the stereochemical outcome of the reaction. This chapter focuses on MBFTs based on recent developments in organocatalysis and transition metal catalysis, as well as multicomponent chemistry. It also aims to demonstrate the scope and synthetic potential of the above-mentioned classes of MBFTs in the synthesis of BRMs, with illustrative examples ranging from natural products to complex pharmaceuticals.

Original languageEnglish
Title of host publicationStereoselective Multiple Bond-Forming Transformations in Organic Synthesis
Number of pages30
ISBN (Electronic)9781119006220
ISBN (Print)9781118672716
Publication statusPublished - 24 Apr 2015


  • Biologically relevant molecules (BRMs)
  • C-C bond formations
  • Complex pharmaceuticals
  • Drug discovery
  • Organocatalysis
  • Synthetic chemists


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