Synthesis of Densely Functionalized Pyrimidouracils by Nickel(II)-Catalyzed Isocyanide Insertion

Jurriën W. Collet, Bénédicte Morel, Hung Chien Lin, Thomas R. Roose, Pieter Mampuys, Romano V.A. Orru*, Eelco Ruijter, Bert U.W. Maes

*Corresponding author for this work

Research output: Contribution to JournalArticle


A robust nickel-catalyzed oxidative isocyanide insertion/C-H amination by reaction of readily available N-uracil-amidines with isocyanides affording polysubstituted pyrimidouracils has been reported. The reaction proceeds in moderate to quantitative yield, under mild conditions (i.e., green solvent, air atmosphere, moderate temperature). The broad range of structurally diverse isocyanides and N-uracil-amidines that are tolerated make this method an interesting alternative to the currently available procedures toward pyrimidouracils.

Original languageEnglish
Pages (from-to)914-919
Number of pages6
JournalOrganic Letters
Issue number3
Publication statusPublished - 1 Jan 2020


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