Abstract
A robust nickel-catalyzed oxidative isocyanide insertion/C-H amination by reaction of readily available N-uracil-amidines with isocyanides affording polysubstituted pyrimidouracils has been reported. The reaction proceeds in moderate to quantitative yield, under mild conditions (i.e., green solvent, air atmosphere, moderate temperature). The broad range of structurally diverse isocyanides and N-uracil-amidines that are tolerated make this method an interesting alternative to the currently available procedures toward pyrimidouracils.
Original language | English |
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Pages (from-to) | 914-919 |
Number of pages | 6 |
Journal | Organic letters |
Volume | 22 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1 Jan 2020 |
Funding
Financial support from The Netherlands Organization for Scientific Research (NWO), the Research Foundation Flanders (FWO), the Francqui Foundation, and the University of Antwerp (BOF Scholarship to J.W.C.) is gratefully acknowledged. The research leading to these results has also received support from the Innovative Medicines Initiative ( www.imi.europa.eu ) Joint Undertaking under Grant Agreement No. 115360, resources of which are composed of financial contribution from the European Union’s Seventh Framework Programme (FP7/2007-2013) and EFPIA companies’ in kind contribution.
Funders | Funder number |
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Francqui Foundation | |
Seventh Framework Programme | 115360 |
Fonds Wetenschappelijk Onderzoek | |
Nederlandse Organisatie voor Wetenschappelijk Onderzoek | |
Bijzonder Onderzoeksfonds UGent | |
Universiteit Antwerpen | |
Innovative Medicines Initiative |