Abstract
Natural products cover a diversity space not yet available from synthetic libraries, with an unrivalled success rate as drug leads. The combinatorial synthesis of non-oligomeric natural-product-based libraries, however, is still limited to few examples because access to easily modified units strongly depends on the availability of a core structure either from a natural source, or through a suitable synthetic route. Only a few resourceful groups have managed the latter approach for more demanding multifunctional natural drug leads, such as epothilones.
Original language | English |
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Pages (from-to) | 303-309 |
Journal | Current Opinion in Chemical Biology |
Volume | 4 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2000 |