Synthesis of natural-product-based compound libraries

L.A. Wessjohann

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Natural products cover a diversity space not yet available from synthetic libraries, with an unrivalled success rate as drug leads. The combinatorial synthesis of non-oligomeric natural-product-based libraries, however, is still limited to few examples because access to easily modified units strongly depends on the availability of a core structure either from a natural source, or through a suitable synthetic route. Only a few resourceful groups have managed the latter approach for more demanding multifunctional natural drug leads, such as epothilones.
Original languageEnglish
Pages (from-to)303-309
JournalCurrent Opinion in Chemical Biology
Volume4
Issue number3
DOIs
Publication statusPublished - 2000

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