Synthesis of Quinazolin-4-ones by Copper-Catalyzed Isocyanide Insertion

Jurriën W. Collet, Edith A. Van Der Nol, Tom R. Roose, Bert U.W. Maes, Eelco Ruijter, Romano V.A. Orru*

*Corresponding author for this work

Research output: Contribution to JournalArticleAcademicpeer-review


Herein, we report a novel copper-catalyzed imidoylative cross-coupling/cyclocondensation reaction between 2-isocyanobenzoates and amines efficiently producing quinazolin-4-ones. The reaction utilizes Cu(II) acetate as an environmentally benign catalyst in combination with a mild base and proceeds well in anisole, a recommended, sustainable solvent. Additionally, the reaction does not require dry conditions or inert atmospheres for optimal performance. The scope of this isocyanide insertion reaction is rather broad, tolerating various functionalized isocyanobenzoates and a range of substituted amines, although the use of aromatic amines as nucleophiles requires microwave heating.

Original languageEnglish
Pages (from-to)7378-7385
Number of pages8
JournalJournal of Organic Chemistry
Issue number11
Early online date13 May 2020
Publication statusPublished - 5 Jun 2020


Financial support from The Netherlands Organization for Scientific Research (NWO), the Research Foundation Flanders (FWO), the Francqui Foundation, and the University of Antwerp (BOF Scholarship to J.W.C.) is gratefully acknowledged.

FundersFunder number
Francqui Foundation
Netherlands Organization for Scientific Research
Fonds Wetenschappelijk Onderzoek
Nederlandse Organisatie voor Wetenschappelijk Onderzoek
Bijzonder Onderzoeksfonds UGent
Universiteit Antwerpen
Fondation Francqui - Stichting


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