Synthesis of tetracyclic spiroindolines by an interrupted Bischler-Napieralski reaction: total synthesis of akuammicine

Matteo Faltracco; Eelco Ruijter

doi:10.1039/d1ob01966j

Synthesis of tetracyclic spiroindolines by an interrupted Bischler-Napieralski reaction: total synthesis of akuammicine

Matteo Faltracco, Eelco Ruijter^*

^*Corresponding author for this work

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Judicious substrate design allows interruption of the classical Bischler-Napieralski reaction, providing access to a range of diversely substituted tetracyclic spiroindolines. These complex polycyclic scaffolds are valuable building blocks for the construction of indole alkaloids, as showcased in a concise total synthesis of (±)-akuammicine.

Original language	English
Pages (from-to)	9641-9644
Number of pages	4
Journal	Organic and Biomolecular Chemistry
Volume	19
Issue number	44
Early online date	27 Oct 2021
DOIs	https://doi.org/10.1039/d1ob01966j
Publication status	Published - 28 Nov 2021

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© The Royal Society of Chemistry 2021.

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title = "Synthesis of tetracyclic spiroindolines by an interrupted Bischler-Napieralski reaction: total synthesis of akuammicine",

abstract = "Judicious substrate design allows interruption of the classical Bischler-Napieralski reaction, providing access to a range of diversely substituted tetracyclic spiroindolines. These complex polycyclic scaffolds are valuable building blocks for the construction of indole alkaloids, as showcased in a concise total synthesis of (±)-akuammicine.",

author = "Matteo Faltracco and Eelco Ruijter",

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Synthesis of tetracyclic spiroindolines by an interrupted Bischler-Napieralski reaction: total synthesis of akuammicine

Abstract

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