Synthesis of the Tripeptides Tyr-Thr-Lys Phosphorylated with Isopropyl Methyl- and (Deuteromethyl)phosphonochloridates as Reference Standards for the Analysis of Biomedical Samples

I.A. Rodin; T.M. Baygildiev; V.I. Krylov; V.N. Osipov; I.I. Krylov; V.A. Yashkir; I.V. Rybalchenko

doi:10.1134/S1070363219100189

Synthesis of the Tripeptides Tyr-Thr-Lys Phosphorylated with Isopropyl Methyl- and (Deuteromethyl)phosphonochloridates as Reference Standards for the Analysis of Biomedical Samples

I.A. Rodin, T.M. Baygildiev, V.I. Krylov, V.N. Osipov, I.I. Krylov, V.A. Yashkir, I.V. Rybalchenko

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

© 2019, Pleiades Publishing, Ltd.A procedure for the phosphorylation of the tripeptide Tyr-Thr-Lys with isopropyl methyl- or (deuteromethyl)phosphonochloridate is developed. The phosphorylated tripeptides are intended for use as reference standards in the analysis of blood samples of people suspected to have been exposed to acetylcholinesterase inhibitors. Conditions of hromatographic separation and purification of the synthesized compounds are determined and optimized, which ensures the preparation of high-purity phosphorylated tripeptides.

Original language	English
Pages (from-to)	2103-2107
Journal	Russian Journal of General Chemistry
Volume	89
Issue number	10
DOIs	https://doi.org/10.1134/S1070363219100189
Publication status	Published - 1 Oct 2019
Externally published	Yes

Funding

This work was supported by the Russian Science Foundation (grant no. 19-13-00057) for Lomonosov Moscow State University.

Funders	Funder number
Russian Science Foundation	19-13-00057

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10.1134/S1070363219100189

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Rodin, I. A., Baygildiev, T. M., Krylov, V. I., Osipov, V. N., Krylov, I. I., Yashkir, V. A., & Rybalchenko, I. V. (2019). Synthesis of the Tripeptides Tyr-Thr-Lys Phosphorylated with Isopropyl Methyl- and (Deuteromethyl)phosphonochloridates as Reference Standards for the Analysis of Biomedical Samples. Russian Journal of General Chemistry, 89(10), 2103-2107. https://doi.org/10.1134/S1070363219100189

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title = "Synthesis of the Tripeptides Tyr-Thr-Lys Phosphorylated with Isopropyl Methyl- and (Deuteromethyl)phosphonochloridates as Reference Standards for the Analysis of Biomedical Samples",

abstract = "{\textcopyright} 2019, Pleiades Publishing, Ltd.A procedure for the phosphorylation of the tripeptide Tyr-Thr-Lys with isopropyl methyl- or (deuteromethyl)phosphonochloridate is developed. The phosphorylated tripeptides are intended for use as reference standards in the analysis of blood samples of people suspected to have been exposed to acetylcholinesterase inhibitors. Conditions of hromatographic separation and purification of the synthesized compounds are determined and optimized, which ensures the preparation of high-purity phosphorylated tripeptides.",

author = "I.A. Rodin and T.M. Baygildiev and V.I. Krylov and V.N. Osipov and I.I. Krylov and V.A. Yashkir and I.V. Rybalchenko",

year = "2019",

month = oct,

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doi = "10.1134/S1070363219100189",

language = "English",

volume = "89",

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journal = "Russian Journal of General Chemistry",

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Rodin, IA, Baygildiev, TM, Krylov, VI, Osipov, VN, Krylov, II, Yashkir, VA & Rybalchenko, IV 2019, 'Synthesis of the Tripeptides Tyr-Thr-Lys Phosphorylated with Isopropyl Methyl- and (Deuteromethyl)phosphonochloridates as Reference Standards for the Analysis of Biomedical Samples', Russian Journal of General Chemistry, vol. 89, no. 10, pp. 2103-2107. https://doi.org/10.1134/S1070363219100189

Synthesis of the Tripeptides Tyr-Thr-Lys Phosphorylated with Isopropyl Methyl- and (Deuteromethyl)phosphonochloridates as Reference Standards for the Analysis of Biomedical Samples. / Rodin, I.A.; Baygildiev, T.M.; Krylov, V.I. et al.
In: Russian Journal of General Chemistry, Vol. 89, No. 10, 01.10.2019, p. 2103-2107.

Research output: Contribution to Journal › Article › Academic › peer-review

TY - JOUR

T1 - Synthesis of the Tripeptides Tyr-Thr-Lys Phosphorylated with Isopropyl Methyl- and (Deuteromethyl)phosphonochloridates as Reference Standards for the Analysis of Biomedical Samples

AU - Rodin, I.A.

AU - Baygildiev, T.M.

AU - Krylov, V.I.

AU - Osipov, V.N.

AU - Krylov, I.I.

AU - Yashkir, V.A.

AU - Rybalchenko, I.V.

PY - 2019/10/1

Y1 - 2019/10/1

N2 - © 2019, Pleiades Publishing, Ltd.A procedure for the phosphorylation of the tripeptide Tyr-Thr-Lys with isopropyl methyl- or (deuteromethyl)phosphonochloridate is developed. The phosphorylated tripeptides are intended for use as reference standards in the analysis of blood samples of people suspected to have been exposed to acetylcholinesterase inhibitors. Conditions of hromatographic separation and purification of the synthesized compounds are determined and optimized, which ensures the preparation of high-purity phosphorylated tripeptides.

AB - © 2019, Pleiades Publishing, Ltd.A procedure for the phosphorylation of the tripeptide Tyr-Thr-Lys with isopropyl methyl- or (deuteromethyl)phosphonochloridate is developed. The phosphorylated tripeptides are intended for use as reference standards in the analysis of blood samples of people suspected to have been exposed to acetylcholinesterase inhibitors. Conditions of hromatographic separation and purification of the synthesized compounds are determined and optimized, which ensures the preparation of high-purity phosphorylated tripeptides.

U2 - 10.1134/S1070363219100189

DO - 10.1134/S1070363219100189

M3 - Article

SN - 1070-3632

VL - 89

SP - 2103

EP - 2107

JO - Russian Journal of General Chemistry

JF - Russian Journal of General Chemistry

IS - 10

ER -

Synthesis of the Tripeptides Tyr-Thr-Lys Phosphorylated with Isopropyl Methyl- and (Deuteromethyl)phosphonochloridates as Reference Standards for the Analysis of Biomedical Samples

Abstract

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