Systematic Review: Molecular Studies of Common Genetic Variation in Child and Adolescent Psychiatric Disorders

Wonuola A. Akingbuwa; Anke R. Hammerschlag; Meike Bartels; Christel M. Middeldorp

doi:10.1016/j.jaac.2021.03.020

Systematic Review: Molecular Studies of Common Genetic Variation in Child and Adolescent Psychiatric Disorders

Wonuola A. Akingbuwa
, Anke R. Hammerschlag
, Meike Bartels
, Christel M. Middeldorp

Research output: Contribution to Journal › Review article › Academic › peer-review

Abstract

Objective
A systematic review of studies using molecular genetics and statistical approaches to investigate the role of common genetic variation in the development, persistence, and comorbidity of childhood psychiatric traits was conducted.
Method
A literature review was performed using the PubMed database, following PRISMA guidelines. There were 131 studies meeting inclusion criteria, having investigated at least one type of childhood-onset or childhood-measured psychiatric disorder or trait with the aim of identifying trait-associated common genetic variants, estimating the contribution of single nucleotide polymorphisms (SNPs) to the amount of variance explained (SNP-based heritability), investigating genetic overlap between psychiatric traits, or investigating whether the stability in traits or the association with adult traits is explained by genetic factors.
Results
The first robustly associated genetic variants have started to be identified for childhood psychiatric traits. There were substantial contributions of common genetic variants to many traits, with variation in single nucleotide polymorphism heritability estimates depending on age and raters. Moreover, genetic variants also appeared to explain comorbidity as well as stability across a range of psychiatric traits in childhood and across the life span.
Conclusion
Common genetic variation plays a substantial role in childhood psychiatric traits. Increased sample sizes will lead to increased power to identify genetic variants and to understand genetic architecture, which will ultimately be beneficial to targeted and prevention strategies. This can be achieved by harmonizing phenotype measurements, as is already proposed by large international consortia and by including the collection of genetic material in every study.

Original language	English
Pages (from-to)	227-242
Number of pages	18
Journal	Journal of the American Academy of Child and Adolescent Psychiatry
Volume	61
Issue number	2
Early online date	28 Apr 2021
DOIs	https://doi.org/10.1016/j.jaac.2021.03.020
Publication status	Published - Feb 2022

Funding

This project has received funding from the European Union's Horizon 2020 research and innovation programme, Marie Skłodowska Curie Actions Innovative Training Networks (MSCA-ITN-2016) under grant agreement No. 721567. A.R.H. is supported by the Children's Hospital Foundation and University of Queensland strategic funding. M.B. is funded by an ERC Consolidator Grant (WELL-BEING 771057). The funding sources had no involvement in the study design, writing of the report, or the decision to submit the article for publication. Author Contributions Conceptualization: Akingbuwa, Hammerschlag, Bartels, Middeldorp Data curation: Akingbuwa, Hammerschlag, Bartels, Middeldorp Formal analysis: Akingbuwa, Hammerschlag, Bartels, Middeldorp Funding acquisition: Middeldorp Investigation: Akingbuwa, Hammerschlag, Bartels, Middeldorp Methodology: Akingbuwa, Hammerschlag, Bartels, Middeldorp Supervision: Hammerschlag, Bartels, Middeldorp Writing – original draft: Akingbuwa, Hammerschlag, Bartels, Middeldorp Writing – review and editing: Akingbuwa, Hammerschlag, Bartels, Middeldorp Disclosure: Prof. Middeldorp has received grant or research support from the National Health and Medical Research Council, the European Union, and the Australian ADHD Professional Association. She has served as associate editor of the American Journal of Medical Genetics Part B. Dr. Hammerschlag, Prof. Bartels, and Ms. Akingbuwa have reported no biomedical financial interests or potential conflicts of interest.

Funders	Funder number
Marie Skłodowska Curie Actions Innovative Training Networks	MSCA-ITN-2016, 721567
Horizon 2020 Framework Programme	771057
Children's Hospital Foundation
Royal Children's Hospital Foundation
European Commission
European Research Council
National Health and Medical Research Council
University of Queensland
Horizon 2020

Access to Document

10.1016/j.jaac.2021.03.020

https://linkinghub.elsevier.com/retrieve/pii/S0890856721002380

Persistent URL (handle)

Persistent link

Cite this

@article{0e9c5a9c70874c04a675a9a97edc34ce,

title = "Systematic Review: Molecular Studies of Common Genetic Variation in Child and Adolescent Psychiatric Disorders",

abstract = "Objective A systematic review of studies using molecular genetics and statistical approaches to investigate the role of common genetic variation in the development, persistence, and comorbidity of childhood psychiatric traits was conducted. Method A literature review was performed using the PubMed database, following PRISMA guidelines. There were 131 studies meeting inclusion criteria, having investigated at least one type of childhood-onset or childhood-measured psychiatric disorder or trait with the aim of identifying trait-associated common genetic variants, estimating the contribution of single nucleotide polymorphisms (SNPs) to the amount of variance explained (SNP-based heritability), investigating genetic overlap between psychiatric traits, or investigating whether the stability in traits or the association with adult traits is explained by genetic factors. Results The first robustly associated genetic variants have started to be identified for childhood psychiatric traits. There were substantial contributions of common genetic variants to many traits, with variation in single nucleotide polymorphism heritability estimates depending on age and raters. Moreover, genetic variants also appeared to explain comorbidity as well as stability across a range of psychiatric traits in childhood and across the life span. Conclusion Common genetic variation plays a substantial role in childhood psychiatric traits. Increased sample sizes will lead to increased power to identify genetic variants and to understand genetic architecture, which will ultimately be beneficial to targeted and prevention strategies. This can be achieved by harmonizing phenotype measurements, as is already proposed by large international consortia and by including the collection of genetic material in every study.",

author = "Akingbuwa, \{Wonuola A.\} and Hammerschlag, \{Anke R.\} and Meike Bartels and Middeldorp, \{Christel M.\}",

year = "2022",

month = feb,

doi = "10.1016/j.jaac.2021.03.020",

language = "English",

volume = "61",

pages = "227--242",

journal = "Journal of the American Academy of Child and Adolescent Psychiatry",

issn = "0890-8567",

publisher = "Elsevier Inc.",

number = "2",

}

Systematic Review: Molecular Studies of Common Genetic Variation in Child and Adolescent Psychiatric Disorders. / Akingbuwa, Wonuola A.; Hammerschlag, Anke R.; Bartels, Meike et al.
In: Journal of the American Academy of Child and Adolescent Psychiatry, Vol. 61, No. 2, 02.2022, p. 227-242.

Research output: Contribution to Journal › Review article › Academic › peer-review

TY - JOUR

T1 - Systematic Review: Molecular Studies of Common Genetic Variation in Child and Adolescent Psychiatric Disorders

AU - Akingbuwa, Wonuola A.

AU - Hammerschlag, Anke R.

AU - Bartels, Meike

AU - Middeldorp, Christel M.

PY - 2022/2

Y1 - 2022/2

N2 - Objective A systematic review of studies using molecular genetics and statistical approaches to investigate the role of common genetic variation in the development, persistence, and comorbidity of childhood psychiatric traits was conducted. Method A literature review was performed using the PubMed database, following PRISMA guidelines. There were 131 studies meeting inclusion criteria, having investigated at least one type of childhood-onset or childhood-measured psychiatric disorder or trait with the aim of identifying trait-associated common genetic variants, estimating the contribution of single nucleotide polymorphisms (SNPs) to the amount of variance explained (SNP-based heritability), investigating genetic overlap between psychiatric traits, or investigating whether the stability in traits or the association with adult traits is explained by genetic factors. Results The first robustly associated genetic variants have started to be identified for childhood psychiatric traits. There were substantial contributions of common genetic variants to many traits, with variation in single nucleotide polymorphism heritability estimates depending on age and raters. Moreover, genetic variants also appeared to explain comorbidity as well as stability across a range of psychiatric traits in childhood and across the life span. Conclusion Common genetic variation plays a substantial role in childhood psychiatric traits. Increased sample sizes will lead to increased power to identify genetic variants and to understand genetic architecture, which will ultimately be beneficial to targeted and prevention strategies. This can be achieved by harmonizing phenotype measurements, as is already proposed by large international consortia and by including the collection of genetic material in every study.

AB - Objective A systematic review of studies using molecular genetics and statistical approaches to investigate the role of common genetic variation in the development, persistence, and comorbidity of childhood psychiatric traits was conducted. Method A literature review was performed using the PubMed database, following PRISMA guidelines. There were 131 studies meeting inclusion criteria, having investigated at least one type of childhood-onset or childhood-measured psychiatric disorder or trait with the aim of identifying trait-associated common genetic variants, estimating the contribution of single nucleotide polymorphisms (SNPs) to the amount of variance explained (SNP-based heritability), investigating genetic overlap between psychiatric traits, or investigating whether the stability in traits or the association with adult traits is explained by genetic factors. Results The first robustly associated genetic variants have started to be identified for childhood psychiatric traits. There were substantial contributions of common genetic variants to many traits, with variation in single nucleotide polymorphism heritability estimates depending on age and raters. Moreover, genetic variants also appeared to explain comorbidity as well as stability across a range of psychiatric traits in childhood and across the life span. Conclusion Common genetic variation plays a substantial role in childhood psychiatric traits. Increased sample sizes will lead to increased power to identify genetic variants and to understand genetic architecture, which will ultimately be beneficial to targeted and prevention strategies. This can be achieved by harmonizing phenotype measurements, as is already proposed by large international consortia and by including the collection of genetic material in every study.

U2 - 10.1016/j.jaac.2021.03.020

DO - 10.1016/j.jaac.2021.03.020

M3 - Review article

SN - 0890-8567

VL - 61

SP - 227

EP - 242

JO - Journal of the American Academy of Child and Adolescent Psychiatry

JF - Journal of the American Academy of Child and Adolescent Psychiatry

IS - 2

ER -

Systematic Review: Molecular Studies of Common Genetic Variation in Child and Adolescent Psychiatric Disorders

Abstract

Funding

Access to Document

Persistent URL (handle)

Fingerprint

Cite this