Systems Biology: the elements and principles of life.

H.V. Westerhoff, C. Winder, H. Messiha, E. Simeonidis, M. Adamczyk, M. Verma, F.J. Bruggeman, W. Dunn

    Research output: Contribution to JournalArticleAcademicpeer-review

    Abstract

    Systems Biology has a mission that puts it at odds with traditional paradigms of physics and molecular biology, such as the simplicity requested by Occam's razor and minimum energy/maximal efficiency. By referring to biochemical experiments on control and regulation, and on flux balancing in yeast, we show that these paradigms are inapt. Systems Biology does not quite converge with biology either: Although it certainly requires accurate 'stamp collecting', it discovers quantitative laws. Systems Biology is a science of its own, discovering own fundamental principles, some of which we identify here. Crown Copyright © 2009.
    Original languageEnglish
    Pages (from-to)3882-3890
    JournalFEBS Letters
    Volume583
    DOIs
    Publication statusPublished - 2009

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