T-Screen as a tool to identify thyroid hormone receptor active compounds

A.C. Gutleb; I.A.T.M. Meerts; J.H. Bergsma; M. Schriks; A.J. Murk

doi:10.1016/j.etap.2004.06.003

T-Screen as a tool to identify thyroid hormone receptor active compounds

A.C. Gutleb, I.A.T.M. Meerts, J.H. Bergsma, M. Schriks, A.J. Murk

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

The T-Screen represents an in vitro bioassay based on thyroid hormone dependent cell proliferation of a rat pituitary tumour cell line (GH3) in serum-free medium. It can be used to study interference of compounds with thyroid hormone at the cellular level, thus bridging the gap between limitations of assays using either isolated molecules (enzymes, transport proteins) or complex in vivo experiments with all the complex feedback mechanisms present. Compounds are tested both in the absence and presence of thyroid hormone (EC

Original language	English
Pages (from-to)	231-238
Number of pages	8
Journal	Environmental Toxicology and Pharmacology
Volume	19
DOIs	https://doi.org/10.1016/j.etap.2004.06.003
Publication status	Published - 2004

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abstract = "The T-Screen represents an in vitro bioassay based on thyroid hormone dependent cell proliferation of a rat pituitary tumour cell line (GH3) in serum-free medium. It can be used to study interference of compounds with thyroid hormone at the cellular level, thus bridging the gap between limitations of assays using either isolated molecules (enzymes, transport proteins) or complex in vivo experiments with all the complex feedback mechanisms present. Compounds are tested both in the absence and presence of thyroid hormone (EC",

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AU - Gutleb, A.C.

AU - Meerts, I.A.T.M.

AU - Bergsma, J.H.

AU - Schriks, M.

AU - Murk, A.J.

PY - 2004

Y1 - 2004

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AB - The T-Screen represents an in vitro bioassay based on thyroid hormone dependent cell proliferation of a rat pituitary tumour cell line (GH3) in serum-free medium. It can be used to study interference of compounds with thyroid hormone at the cellular level, thus bridging the gap between limitations of assays using either isolated molecules (enzymes, transport proteins) or complex in vivo experiments with all the complex feedback mechanisms present. Compounds are tested both in the absence and presence of thyroid hormone (EC

U2 - 10.1016/j.etap.2004.06.003

DO - 10.1016/j.etap.2004.06.003

M3 - Article

SN - 1382-6689

VL - 19

SP - 231

EP - 238

JO - Environmental Toxicology and Pharmacology

JF - Environmental Toxicology and Pharmacology

ER -

T-Screen as a tool to identify thyroid hormone receptor active compounds

Abstract

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