T-Screen as a tool to identify thyroid hormone receptor active compounds

A.C. Gutleb, I.A.T.M. Meerts, J.H. Bergsma, M. Schriks, A.J. Murk

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

The T-Screen represents an in vitro bioassay based on thyroid hormone dependent cell proliferation of a rat pituitary tumour cell line (GH3) in serum-free medium. It can be used to study interference of compounds with thyroid hormone at the cellular level, thus bridging the gap between limitations of assays using either isolated molecules (enzymes, transport proteins) or complex in vivo experiments with all the complex feedback mechanisms present. Compounds are tested both in the absence and presence of thyroid hormone (EC
Original languageEnglish
Pages (from-to)231-238
Number of pages8
JournalEnvironmental Toxicology and Pharmacology
Volume19
DOIs
Publication statusPublished - 2004

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