The motion of neutral molecules in a beam can be manipulated with inhomogeneous electric and magnetic fields. Static fields can be used to deflect or focus molecules, whereas time-varying fields can be used to decelerate or accelerate beams of molecules to any desired velocity. We review the possibilities that this molecular-beam technology offers, ranging from ultrahigh-resolution spectroscopy using molecular fountains to novel crossed-beam scattering experiments. © 2008 Macmillan Publishers Limited. All rights reserved.