Targeted imaging of integrins in cancer tissues using photocleavable Ru(ii) polypyridine complexes as mass-tags

Jiaying Han; Jing Sun; Shanshan Song; Leonie Beljaars; Geny M.M. Groothuis; Hjalmar Permentier; Rainer Bischoff; Gyorgy B. Halmos; Cornelia J. Verhoeven; Erika R. Amstalden van Hove; Peter Horvatovich; Angela Casini

doi:10.1039/d0cc00774a

Targeted imaging of integrins in cancer tissues using photocleavable Ru(ii) polypyridine complexes as mass-tags

Jiaying Han, Jing Sun, Shanshan Song, Leonie Beljaars, Geny M.M. Groothuis, Hjalmar Permentier, Rainer Bischoff, Gyorgy B. Halmos, Cornelia J. Verhoeven, Erika R. Amstalden van Hove, Peter Horvatovich^*, Angela Casini

^*Corresponding author for this work

Research output: Contribution to Journal › Article › Academic › peer-review

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Abstract

Targeted epitope-based mass spectrometry imaging (MSI) utilizes laser cleavable mass-tags bound to targeting moieties for detecting proteins in tissue sections. Our work constitutes the first proof-of-concept of a novel laser desorption ionization (LDI)-MSI strategy using photocleavable Ru(ii) polypyridine complexes as mass-tags for imaging of integrins avß3 in human cancer tissues.

Original language	English
Pages (from-to)	5941-5944
Number of pages	4
Journal	Chemical Communications
Volume	56
Issue number	44
Early online date	21 Apr 2020
DOIs	https://doi.org/10.1039/d0cc00774a
Publication status	Published - 4 Jun 2020

Funding

The University of Groningen is acknowledged for funding. J. H. thanks the China Scholarship Council (CSC) for a PhD fellowship.

Funders	Funder number
Rijksuniversiteit Groningen
China Scholarship Council

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1039/d0cc00774a

Targeted imaging of integrins in cancer tissues using photocleavable Ru(ii) polypyridine complexes as masstagsFinal published version, 1.98 MBLicence: Article 25fa Dutch Copyright Act

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Han, J., Sun, J., Song, S., Beljaars, L., Groothuis, G. M. M., Permentier, H., Bischoff, R., Halmos, G. B., Verhoeven, C. J., Amstalden van Hove, E. R., Horvatovich, P., & Casini, A. (2020). Targeted imaging of integrins in cancer tissues using photocleavable Ru(ii) polypyridine complexes as mass-tags. Chemical Communications, 56(44), 5941-5944. https://doi.org/10.1039/d0cc00774a

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abstract = "Targeted epitope-based mass spectrometry imaging (MSI) utilizes laser cleavable mass-tags bound to targeting moieties for detecting proteins in tissue sections. Our work constitutes the first proof-of-concept of a novel laser desorption ionization (LDI)-MSI strategy using photocleavable Ru(ii) polypyridine complexes as mass-tags for imaging of integrins av{\ss}3 in human cancer tissues.",

author = "Jiaying Han and Jing Sun and Shanshan Song and Leonie Beljaars and Groothuis, \{Geny M.M.\} and Hjalmar Permentier and Rainer Bischoff and Halmos, \{Gyorgy B.\} and Verhoeven, \{Cornelia J.\} and \{Amstalden van Hove\}, \{Erika R.\} and Peter Horvatovich and Angela Casini",

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Han, J, Sun, J, Song, S, Beljaars, L, Groothuis, GMM, Permentier, H, Bischoff, R, Halmos, GB, Verhoeven, CJ, Amstalden van Hove, ER, Horvatovich, P & Casini, A 2020, 'Targeted imaging of integrins in cancer tissues using photocleavable Ru(ii) polypyridine complexes as mass-tags', Chemical Communications, vol. 56, no. 44, pp. 5941-5944. https://doi.org/10.1039/d0cc00774a

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T1 - Targeted imaging of integrins in cancer tissues using photocleavable Ru(ii) polypyridine complexes as mass-tags

AU - Han, Jiaying

AU - Sun, Jing

AU - Song, Shanshan

AU - Beljaars, Leonie

AU - Groothuis, Geny M.M.

AU - Permentier, Hjalmar

AU - Bischoff, Rainer

AU - Halmos, Gyorgy B.

AU - Verhoeven, Cornelia J.

AU - Amstalden van Hove, Erika R.

AU - Horvatovich, Peter

AU - Casini, Angela

PY - 2020/6/4

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Targeted imaging of integrins in cancer tissues using photocleavable Ru(ii) polypyridine complexes as mass-tags

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