Targeting chemokine receptors in chronic inflammatory diseases: An extensive review

P.J. Koelink; S.A. Overbeek; S. Braber; G. Folkerts; P. de Kruijf; M.J. Smit; A.D. Kraneveld

doi:10.1016/j.pharmthera.2011.06.008

Targeting chemokine receptors in chronic inflammatory diseases: An extensive review

P.J. Koelink, S.A. Overbeek, S. Braber, G. Folkerts, P. de Kruijf, M.J. Smit, A.D. Kraneveld

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

The traffic of the different types of immune cells is an important aspect in the immune response. Chemokines are soluble peptides that are able to attract cells by interaction with chemokine receptors on their target cells. Several different chemokines and receptors exist enabling the specific trafficking of different immune cells. In chronic inflammatory disorders there is abundance of immune cells present at the inflammatory site. This review focuses on the role of chemokine receptors in chronic inflammatory disorders of the lungs, intestine, joints, skin and nervous system and the potential of targeting these receptors as therapeutic intervention in these disorders. © 2011 Elsevier Inc. All rights reserved.

Original language	English
Pages (from-to)	1-18
Journal	Pharmacology and Therapeutics
Volume	133
DOIs	https://doi.org/10.1016/j.pharmthera.2011.06.008
Publication status	Published - 2012

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10.1016/j.pharmthera.2011.06.008

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title = "Targeting chemokine receptors in chronic inflammatory diseases: An extensive review",

abstract = "The traffic of the different types of immune cells is an important aspect in the immune response. Chemokines are soluble peptides that are able to attract cells by interaction with chemokine receptors on their target cells. Several different chemokines and receptors exist enabling the specific trafficking of different immune cells. In chronic inflammatory disorders there is abundance of immune cells present at the inflammatory site. This review focuses on the role of chemokine receptors in chronic inflammatory disorders of the lungs, intestine, joints, skin and nervous system and the potential of targeting these receptors as therapeutic intervention in these disorders. {\textcopyright} 2011 Elsevier Inc. All rights reserved.",

author = "P.J. Koelink and S.A. Overbeek and S. Braber and G. Folkerts and {de Kruijf}, P. and M.J. Smit and A.D. Kraneveld",

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AU - Koelink, P.J.

AU - Overbeek, S.A.

AU - Braber, S.

AU - Folkerts, G.

AU - de Kruijf, P.

AU - Smit, M.J.

AU - Kraneveld, A.D.

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AB - The traffic of the different types of immune cells is an important aspect in the immune response. Chemokines are soluble peptides that are able to attract cells by interaction with chemokine receptors on their target cells. Several different chemokines and receptors exist enabling the specific trafficking of different immune cells. In chronic inflammatory disorders there is abundance of immune cells present at the inflammatory site. This review focuses on the role of chemokine receptors in chronic inflammatory disorders of the lungs, intestine, joints, skin and nervous system and the potential of targeting these receptors as therapeutic intervention in these disorders. © 2011 Elsevier Inc. All rights reserved.

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DO - 10.1016/j.pharmthera.2011.06.008

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VL - 133

SP - 1

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JO - Pharmacology and Therapeutics

JF - Pharmacology and Therapeutics

ER -

Targeting chemokine receptors in chronic inflammatory diseases: An extensive review

Abstract

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