Chemokines and their receptors are highly interesting therapeutic targets for pharmaceutical and biotechnology companies. In particular, industrial development pipelines are filled with new chemokine-targeting drugs to treat inflammatory diseases and malignancies. In this review, we specifically highlight antibody-based therapeutics and monoclonal antibodies (mAbs) targeting the chemokine system. Besides discussing pitfalls inherently linked to their discovery, we will elaborate on where progress can be made in the development of novel human therapeutic antibodies directed at the chemokine system. © 2012 Elsevier Ltd. All rights reserved.