Targeting the molecular & cellular pillars of human aging with exercise

Jorming Goh; Esther Wong; Janjira Soh; Andrea Britta Maier; Brian Keith Kennedy

doi:10.1111/febs.16337

Targeting the molecular & cellular pillars of human aging with exercise

Jorming Goh, Esther Wong, Janjira Soh, Andrea Britta Maier, Brian Keith Kennedy^*

^*Corresponding author for this work

Research output: Contribution to Journal › Review article › Academic › peer-review

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Abstract

Biological aging is the main driver of age-associated chronic diseases. In 2014, the United States National Institute of Aging (NIA) sponsored a meeting between several investigators in the field of aging biology, who identified seven biological pillars of aging and a consensus review, “Geroscience: Linking Aging to Chronic Disease,” was published. The pillars of aging demonstrated the conservation of aging pathways in diverse model organisms and thus represent a useful framework with which to study human aging. In this present review, we revisit the seven pillars of aging from the perspective of exercise and discuss how regular physical exercise can modulate these pillars to stave off age-related chronic diseases and maintain functional capacity.

Original language	English
Pages (from-to)	649-668
Number of pages	20
Journal	FEBS Journal
Volume	290
Issue number	3
Early online date	30 Dec 2021
DOIs	https://doi.org/10.1111/febs.16337
Publication status	Published - Feb 2023

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Publisher Copyright:
© 2022 Federation of European Biochemical Societies.

Keywords

aging
disruption in proteostasis
dysregulated stress response
epigenetic drift
inflammaging
macromolecular damage
metabolic dysregulation
stem cell exhaustion

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10.1111/febs.16337

The FEBS Journal - 2022 - Goh - Targeting the molecular cellular pillars of human aging with exerciseFinal published version, 674 KBLicence: Article 25fa Dutch Copyright Act

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Targeting the molecular & cellular pillars of human aging with exercise

Abstract

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Keywords

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