Temporal Dynamics of Beta Power Related to the Stun Effect in Parkinson's Disease Patients after Deep Brain Stimulation Surgery

Martijn G.J. de Neeling; Stijn Geraats; Bart E.K.S. Swinnen; Mariëlle J. Stam; Rob M.A. de Bie; Bernadette van Wijk; P. Rick Schuurman; Arthur W.G. Buijink; Martijn Beudel

doi:10.1002/mds.70042

Temporal Dynamics of Beta Power Related to the Stun Effect in Parkinson's Disease Patients after Deep Brain Stimulation Surgery

Martijn G.J. de Neeling
, Stijn Geraats
, Bart E.K.S. Swinnen
, Mariëlle J. Stam
, Rob M.A. de Bie
, Bernadette van Wijk
, P. Rick Schuurman
, Arthur W.G. Buijink
, Martijn Beudel

Research output: Contribution to Journal › Article › Academic › peer-review

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Abstract

Background. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for patients with advanced Parkinson's disease (PD). Early programming of DBS may be complicated by the postoperative “stun effect,” which also may impact local field potentials (LFPs).

Methods. Percept PC neurostimulators (Medtronic) were used to continuously record LFPs from the STN in 32 PD patients at home during the first 2 months after DBS surgery. Average beta peak power (“beta power”) per day was analyzed using change‐point analysis.

Results. Median beta power across patients showed an upward trend with a changepoint 24 to 40 days after surgery. Median beta power directly following DBS activation did not significantly drop but continued to increase beyond the DBS activation visit.

Conclusion. The neurophysiological stun effect persists for at least 3 weeks and should be taken into consideration when timing and applying sensing‐informed or adaptive DBS based on beta power.

Original language	English
Pages (from-to)	222-227
Number of pages	6
Journal	Movement Disorders
Volume	41
Issue number	1
Early online date	30 Sept 2025
DOIs	https://doi.org/10.1002/mds.70042
Publication status	Published - Jan 2026

Bibliographical note

Funding

P.R.S. is an independent consultant for Medtronic, Boston Scientific, and Elekta. R.M.A.d.B. received research grants from Medtronic, Bial, ZonMw, AMC Foundation, ROMO Foundation, and Stichting ParkinsonFonds, all paid to the institution. B.C.M.v.W. and M.B. received funding from an EU Joint Programme—Neurodegenerative Disease Research (JPND) project. The project is supported through the following funding organizations under the aegis of JPND— www.jpnd.eu : the Netherlands Organisation for Health Research and Development (ZonMw)—the Netherlands.

Funders
JPND
AMC Foundation
EU Joint Programme—Neurodegenerative Disease Research
ROMO Foundation
ZonMw
Netherlands Organisation for Health Research and Development
Medtronic

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10.1002/mds.70042

Movement Disorders - 2025 - Neeling - Temporal Dynamics of Beta Power Related to the Stun Effect in Parkinson s DiseaseFinal published version, 1.15 MBLicence: Article 25fa Dutch Copyright Act

https://pmc.ncbi.nlm.nih.gov/articles/PMC12882053/

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@article{44bf416a7cd2418989f915b46141237a,

title = "Temporal Dynamics of Beta Power Related to the Stun Effect in Parkinson's Disease Patients after Deep Brain Stimulation Surgery",

abstract = "Background. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for patients with advanced Parkinson's disease (PD). Early programming of DBS may be complicated by the postoperative “stun effect,” which also may impact local field potentials (LFPs). Methods. Percept PC neurostimulators (Medtronic) were used to continuously record LFPs from the STN in 32 PD patients at home during the first 2 months after DBS surgery. Average beta peak power (“beta power”) per day was analyzed using change‐point analysis. Results. Median beta power across patients showed an upward trend with a changepoint 24 to 40 days after surgery. Median beta power directly following DBS activation did not significantly drop but continued to increase beyond the DBS activation visit. Conclusion. The neurophysiological stun effect persists for at least 3 weeks and should be taken into consideration when timing and applying sensing‐informed or adaptive DBS based on beta power.",

author = "\{de Neeling\}, \{Martijn G.J.\} and Stijn Geraats and Swinnen, \{Bart E.K.S.\} and Stam, \{Mari{\"e}lle J.\} and \{de Bie\}, \{Rob M.A.\} and \{van Wijk\}, Bernadette and Schuurman, \{P. Rick\} and Buijink, \{Arthur W.G.\} and Martijn Beudel",

note = "{\textcopyright} 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.",

year = "2026",

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doi = "10.1002/mds.70042",

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T1 - Temporal Dynamics of Beta Power Related to the Stun Effect in Parkinson's Disease Patients after Deep Brain Stimulation Surgery

AU - de Neeling, Martijn G.J.

AU - Geraats, Stijn

AU - Swinnen, Bart E.K.S.

AU - Stam, Mariëlle J.

AU - de Bie, Rob M.A.

AU - van Wijk, Bernadette

AU - Schuurman, P. Rick

AU - Buijink, Arthur W.G.

AU - Beudel, Martijn

PY - 2026/1

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N2 - Background. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for patients with advanced Parkinson's disease (PD). Early programming of DBS may be complicated by the postoperative “stun effect,” which also may impact local field potentials (LFPs). Methods. Percept PC neurostimulators (Medtronic) were used to continuously record LFPs from the STN in 32 PD patients at home during the first 2 months after DBS surgery. Average beta peak power (“beta power”) per day was analyzed using change‐point analysis. Results. Median beta power across patients showed an upward trend with a changepoint 24 to 40 days after surgery. Median beta power directly following DBS activation did not significantly drop but continued to increase beyond the DBS activation visit. Conclusion. The neurophysiological stun effect persists for at least 3 weeks and should be taken into consideration when timing and applying sensing‐informed or adaptive DBS based on beta power.

AB - Background. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for patients with advanced Parkinson's disease (PD). Early programming of DBS may be complicated by the postoperative “stun effect,” which also may impact local field potentials (LFPs). Methods. Percept PC neurostimulators (Medtronic) were used to continuously record LFPs from the STN in 32 PD patients at home during the first 2 months after DBS surgery. Average beta peak power (“beta power”) per day was analyzed using change‐point analysis. Results. Median beta power across patients showed an upward trend with a changepoint 24 to 40 days after surgery. Median beta power directly following DBS activation did not significantly drop but continued to increase beyond the DBS activation visit. Conclusion. The neurophysiological stun effect persists for at least 3 weeks and should be taken into consideration when timing and applying sensing‐informed or adaptive DBS based on beta power.

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JO - Movement Disorders

JF - Movement Disorders

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ER -

Temporal Dynamics of Beta Power Related to the Stun Effect in Parkinson's Disease Patients after Deep Brain Stimulation Surgery

Abstract

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