Tenofovir-induced Fanconi syndrome and osteomalacia in two HIV-infected patients: Role of intracellular tenofovir diphosphate levels and review of the literature

M.E. Haverkort, B.W. van der Spek, P.T.A.M. Lips, W.A. Slieker, R. ter Heine, A.D. Huitema, W. Bronsveld

    Research output: Contribution to JournalArticleAcademicpeer-review

    Abstract

    We present 2 human immunodeficiency virus-infected patients with tenofovir disoproxil fumarate-induced Fanconi syndrome, leading to osteomalacia. Intracellular tenofovir diphosphate levels were measured in 1 patient and were found to be very high, with plasma tenofovir levels just slightly elevated. Fibroblast growth factor-23, a phosphaturic hormone, was decreased in both patients and is therefore unlikely to have a pathophysiological role in this pathology. The different potential factors contributing to the development of tenofovir-related kidney proximal tubular dysfunction are discussed and the data presented may help to further elucidate its pathogenesis. © 2011 Informa Healthcare.
    Original languageEnglish
    Pages (from-to)821-826
    JournalScandinavian Journal of Infectious Diseases
    Volume43
    Issue number10
    DOIs
    Publication statusPublished - 2011

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