The 1,2,3-triazole ring as a bioisostere in medicinal chemistry

E. Bonandi, M.S. Christodoulou, G. Fumagalli, D. Perdicchia, G. Rastelli, D. Passarella

Research output: Contribution to JournalReview articleAcademicpeer-review

Abstract

© 2017 Elsevier Ltd1,2,3-Triazole is a well-known scaffold that has a widespread occurrence in different compounds characterized by several bioactivities, such as antimicrobial, antiviral, and antitumor effects. Moreover, the structural features of 1,2,3-triazole enable it to mimic different functional groups, justifying its wide use as a bioisostere for the synthesis of new active molecules. Here, we provide an overview of the 1,2,3-triazole ring as a bioisostere for the design of drug analogs, highlighting relevant recent examples.
Original languageEnglish
Pages (from-to)1572-1581
JournalDrug Discovery Today
Volume22
Issue number10
DOIs
Publication statusPublished - 1 Oct 2017
Externally publishedYes

Fingerprint

Dive into the research topics of 'The 1,2,3-triazole ring as a bioisostere in medicinal chemistry'. Together they form a unique fingerprint.

Cite this