The Acute Inflammatory Response to Absorbed Collagen Sponge is Not Enhanced by BMP-2

H. Huang, D. Wismeijer, E.B. Hunziker, G. Wu

Research output: Contribution to JournalArticleAcademicpeer-review


Absorbed collagen sponge (ACS)/bone morphogenetic protein-2 (BMP-2) are widely used in clinical practise for bone regeneration. However, the application of this product was found to be associated with a significant pro-inflammatory response, particularly in the early phase after implantation. This study aimed to clarify if the pro-inflammatory activities, associated with BMP-2 added to ACS, were related to the physical state of the carrier itself, i.e., a wet or a highly dehydrated state of the ACS, to the local degree of vascularisation and/or to local biomechanical factors. ACS (0.8 cm diameter)/BMP-2 were implanted subcutaneously in the back of 12 eight-week-old Sprague Dawley rats. Two days after surgery, the implanted materials were retrieved and analysed histologically and histomorphometrically. The acute inflammatory response following implantation of ACS was dependent of neither the presence or absence of BMP-2 nor the degree of vascularization in the surrounding tissue nor the hydration state (wet versus dry) of the ACS material at the time of implantation. Differential micro biomechanical factors operating at the implantation site appeared to have an influence on the thickness of inflammation. We conclude that the degree of the early inflammatory response of the ACS/BMP-2 may be associated with the physical and chemical properties of the carrier material itself.

Original languageEnglish
Article number498
Number of pages11
JournalInternational Journal of Molecular Sciences
Issue number3
Publication statusPublished - Mar 2017

Bibliographical note

Part of special issue: Wound Repair and Regeneration


This study was supported by the funds of China Scholarship Council, Natural Science Foundation of China (Grant No. 81400475 and No. 81470724) and Zhejiang Provincial Natural Science Foundation of China (No. LY14H140002, No. LY14H140006 and No. Y17H140023).

FundersFunder number
Zhejiang Provincial Natural Science Foundation of ChinaLY14H140006, LY14H140002, Y17H140023
National Natural Science Foundation of China81470724, 81400475
China Scholarship Council


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