TY - JOUR
T1 - The Adult Netherlands Twin Register: Twenty-Five Years of Survey and Biological Data Collection
AU - Willemsen, G.
AU - Vink, J.M.
AU - Abdellaoui, A.
AU - den Braber, A.
AU - van Beek, J.H.D.A.
AU - Draisma, H.H.M.
AU - van Dongen, J.
AU - van t Ent, D.
AU - Geels, L.M.
AU - van Lien, R.
AU - Ligthart, L.
AU - Kattenberg, V.M.
AU - Mbarek, H.
AU - de Moor, M.H.M.
AU - Neijts, M.
AU - Pool, R.
AU - Stroo, N.
AU - Kluft, C.
AU - Suchiman, H.E.D.
AU - Slagboom, P.E.
AU - de Geus, E.J.C.
AU - Boomsma, D.I.
PY - 2013
Y1 - 2013
N2 - Over the past 25 years, the Adult Netherlands Twin Register (ANTR) has collected a wealth of information on physical and mental health, lifestyle, and personality in adolescents and adults. This article provides an overview of the sources of information available, the main research findings, and an outlook for the future. Between 1991 and 2012, longitudinal surveys were completed by twins, their parents, siblings, spouses, and offspring. Data are available for 33,957 participants, with most individuals having completed two or more surveys. Smaller projects provided in-depth phenotyping, including measurements of the autonomic nervous system, neurocognitive function, and brain imaging. For 46% of the ANTR participants, DNA samples are available and whole genome scans have been obtained in more than 11,000 individuals. These data have resulted in numerous studies on heritability, gene x environment interactions, and causality, as well as gene finding studies. In the future, these studies will continue with collection of additional phenotypes, such as metabolomic and telomere length data, and detailed genetic information provided by DNA and RNA sequencing. Record linkage to national registers will allow the study of morbidity and mortality, thus providing insight into the development of health, lifestyle, and behavior across the lifespan. Copyright © The Authors 2013.
AB - Over the past 25 years, the Adult Netherlands Twin Register (ANTR) has collected a wealth of information on physical and mental health, lifestyle, and personality in adolescents and adults. This article provides an overview of the sources of information available, the main research findings, and an outlook for the future. Between 1991 and 2012, longitudinal surveys were completed by twins, their parents, siblings, spouses, and offspring. Data are available for 33,957 participants, with most individuals having completed two or more surveys. Smaller projects provided in-depth phenotyping, including measurements of the autonomic nervous system, neurocognitive function, and brain imaging. For 46% of the ANTR participants, DNA samples are available and whole genome scans have been obtained in more than 11,000 individuals. These data have resulted in numerous studies on heritability, gene x environment interactions, and causality, as well as gene finding studies. In the future, these studies will continue with collection of additional phenotypes, such as metabolomic and telomere length data, and detailed genetic information provided by DNA and RNA sequencing. Record linkage to national registers will allow the study of morbidity and mortality, thus providing insight into the development of health, lifestyle, and behavior across the lifespan. Copyright © The Authors 2013.
U2 - 10.1017/thg.2012.140
DO - 10.1017/thg.2012.140
M3 - Article
SN - 1832-4274
VL - 16
SP - 271
EP - 281
JO - Twin Research and Human Genetics
JF - Twin Research and Human Genetics
IS - 1
ER -