ABO blood types and their corresponding antigens have long been assumed to be related to different human diseases. So far, smaller studies on the relationship between mental disorders and blood types yielded contradicting results. In this study we analyzed the association between ABO blood types and lifetime major depressive disorder (MDD). We performed a pooled analysis with data from 26 cohorts that are part of the MDD working group of the Psychiatric Genomics Consortium (PGC). The dataset included 37,208 individuals of largely European ancestry of which 41.6% were diagnosed with lifetime MDD. ABO blood types were identified using three single nucleotide polymorphisms in the ABO gene: rs505922, rs8176746 and rs8176747. Regression analyses were performed to assess associations between the individual ABO blood types and MDD diagnosis as well as putative interaction effects with sex. The models were adjusted for sex, cohort and the first ten genetic principal components. The percentage of blood type A was slightly lower in cases than controls while blood type O was more prominent in cases. However, these differences were not statistically significant. Our analyses found no evidence of an association between ABO blood types and major depressive disorder.
Bibliographical noteFunding Information:
L.G. was supported by the German Research Foundation (DFG, grant no. 403694598). S.V. was supported by the German Federal Ministry of Education and Research (BMBF) within the framework of the e:Med research and funding concept (Integrament; grant no. 01ZX1614E). H.J.G. has received travel grants and speakers honoraria from Fresenius Medical Care and Janssen Cilag. He has received research funding from the German Research Foundation, the German Federal Ministry of Education and Research (BMBF), the DAMP Foundation, Fresenius Medical Care, the EU "Joint Programme Neurodegenerative Disorders” (JPND: 01ED1615) and the European Social Fund (ESF). The PGC has received major funding from the US National Institute of Mental Health (5 U01MH109528-03).
The Study of Health in Pomerania (SHIP) is part of the Community Medicine Research net (CMR) ( http://www.medizin.uni-greifswald.de/icm ) of the University Medicine Greifswald, which is supported by the German Federal State of Mecklenburg- West Pomerania. MRI scans in SHIP and SHIP-TREND have been supported by a joint grant from Siemens Healthineers, Erlangen, Germany and the Federal State of Mecklenburg-West Pomerania.
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- Association study
- Blood group
- Blood type
- Psychiatric disorders