The association between genetically determined ABO blood types and major depressive disorder

Linda Garvert; Dorret I. Boomsma; Sandra Van der Auwera; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium

doi:10.1016/j.psychres.2021.113837

The association between genetically determined ABO blood types and major depressive disorder

Linda Garvert^*, Dorret I. Boomsma, Sandra Van der Auwera, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium

^*Corresponding author for this work

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Abstract

ABO blood types and their corresponding antigens have long been assumed to be related to different human diseases. So far, smaller studies on the relationship between mental disorders and blood types yielded contradicting results. In this study we analyzed the association between ABO blood types and lifetime major depressive disorder (MDD). We performed a pooled analysis with data from 26 cohorts that are part of the MDD working group of the Psychiatric Genomics Consortium (PGC). The dataset included 37,208 individuals of largely European ancestry of which 41.6% were diagnosed with lifetime MDD. ABO blood types were identified using three single nucleotide polymorphisms in the ABO gene: rs505922, rs8176746 and rs8176747. Regression analyses were performed to assess associations between the individual ABO blood types and MDD diagnosis as well as putative interaction effects with sex. The models were adjusted for sex, cohort and the first ten genetic principal components. The percentage of blood type A was slightly lower in cases than controls while blood type O was more prominent in cases. However, these differences were not statistically significant. Our analyses found no evidence of an association between ABO blood types and major depressive disorder.

Original language	English
Article number	113837
Pages (from-to)	1-5
Number of pages	5
Journal	Psychiatry Research
Volume	299
Early online date	24 Feb 2021
DOIs	https://doi.org/10.1016/j.psychres.2021.113837
Publication status	Published - May 2021

Bibliographical note

Funding Information:
L.G. was supported by the German Research Foundation (DFG, grant no. 403694598). S.V. was supported by the German Federal Ministry of Education and Research (BMBF) within the framework of the e:Med research and funding concept (Integrament; grant no. 01ZX1614E). H.J.G. has received travel grants and speakers honoraria from Fresenius Medical Care and Janssen Cilag. He has received research funding from the German Research Foundation, the German Federal Ministry of Education and Research (BMBF), the DAMP Foundation, Fresenius Medical Care, the EU "Joint Programme Neurodegenerative Disorders” (JPND: 01ED1615) and the European Social Fund (ESF). The PGC has received major funding from the US National Institute of Mental Health (5 U01MH109528-03).

Funding Information:
The Study of Health in Pomerania (SHIP) is part of the Community Medicine Research net (CMR) ( http://www.medizin.uni-greifswald.de/icm ) of the University Medicine Greifswald, which is supported by the German Federal State of Mecklenburg- West Pomerania. MRI scans in SHIP and SHIP-TREND have been supported by a joint grant from Siemens Healthineers, Erlangen, Germany and the Federal State of Mecklenburg-West Pomerania.

Publisher Copyright:
© 2021

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

Funding

L.G. was supported by the German Research Foundation (DFG, grant no. 403694598). S.V. was supported by the German Federal Ministry of Education and Research (BMBF) within the framework of the e:Med research and funding concept (Integrament; grant no. 01ZX1614E). H.J.G. has received travel grants and speakers honoraria from Fresenius Medical Care and Janssen Cilag. He has received research funding from the German Research Foundation, the German Federal Ministry of Education and Research (BMBF), the DAMP Foundation, Fresenius Medical Care, the EU "Joint Programme Neurodegenerative Disorders” (JPND: 01ED1615) and the European Social Fund (ESF). The PGC has received major funding from the US National Institute of Mental Health (5 U01MH109528-03). The Study of Health in Pomerania (SHIP) is part of the Community Medicine Research net (CMR) ( http://www.medizin.uni-greifswald.de/icm ) of the University Medicine Greifswald, which is supported by the German Federal State of Mecklenburg- West Pomerania. MRI scans in SHIP and SHIP-TREND have been supported by a joint grant from Siemens Healthineers, Erlangen, Germany and the Federal State of Mecklenburg-West Pomerania.

Funders	Funder number
CMR
Federal State of Mecklenburg-West Pomerania
German Federal State of Mecklenburg- West Pomerania
National Institute of Mental Health	U01MH109528
Fresenius Medical Care North America
European Commission	01ED1615
Deutsche Forschungsgemeinschaft	403694598
Bundesministerium für Bildung und Forschung	01ZX1614E
European Social Fund
Damp Stiftung

Keywords

Association study
Blood group
Blood type
Depression
MDD
PGC
Psychiatric disorders

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.psychres.2021.113837

The association between genetically determined ABO blood types and major depressive disorderFinal published version, 762 KBLicence: Article 25fa Dutch Copyright Act

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title = "The association between genetically determined ABO blood types and major depressive disorder",

abstract = "ABO blood types and their corresponding antigens have long been assumed to be related to different human diseases. So far, smaller studies on the relationship between mental disorders and blood types yielded contradicting results. In this study we analyzed the association between ABO blood types and lifetime major depressive disorder (MDD). We performed a pooled analysis with data from 26 cohorts that are part of the MDD working group of the Psychiatric Genomics Consortium (PGC). The dataset included 37,208 individuals of largely European ancestry of which 41.6% were diagnosed with lifetime MDD. ABO blood types were identified using three single nucleotide polymorphisms in the ABO gene: rs505922, rs8176746 and rs8176747. Regression analyses were performed to assess associations between the individual ABO blood types and MDD diagnosis as well as putative interaction effects with sex. The models were adjusted for sex, cohort and the first ten genetic principal components. The percentage of blood type A was slightly lower in cases than controls while blood type O was more prominent in cases. However, these differences were not statistically significant. Our analyses found no evidence of an association between ABO blood types and major depressive disorder.",

keywords = "Association study, Blood group, Blood type, Depression, MDD, PGC, Psychiatric disorders",

author = "Linda Garvert and Baune, {Bernhard T.} and Klaus Berger and Boomsma, {Dorret I.} and Gerome Breen and Andreas Greinacher and Hamilton, {Steven P.} and Levinson, {Douglas F.} and Lewis, {Cathryn M.} and Susanne Lucae and Magnusson, {Patrik K.E.} and Martin, {Nicholas G.} and McIntosh, {Andrew M.} and Ole Mors and Bertram M{\"u}ller-Myhsok and Penninx, {Brenda W.J.H.} and Perlis, {Roy H.} and Giorgio Pistis and Potash, {James B.} and Martin Preisig and Marcella Rietschel and Jianxin Shi and Smoller, {Jordan W.} and Henning Tiemeier and Rudolf Uher and Uwe V{\"o}lker and Henry V{\"o}lzke and Weissman, {Myrna M.} and Grabe, {Hans J.} and {Van der Auwera}, Sandra and {Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium}",

note = "Funding Information: L.G. was supported by the German Research Foundation (DFG, grant no. 403694598). S.V. was supported by the German Federal Ministry of Education and Research (BMBF) within the framework of the e:Med research and funding concept (Integrament; grant no. 01ZX1614E). H.J.G. has received travel grants and speakers honoraria from Fresenius Medical Care and Janssen Cilag. He has received research funding from the German Research Foundation, the German Federal Ministry of Education and Research (BMBF), the DAMP Foundation, Fresenius Medical Care, the EU {"}Joint Programme Neurodegenerative Disorders” (JPND: 01ED1615) and the European Social Fund (ESF). The PGC has received major funding from the US National Institute of Mental Health (5 U01MH109528-03). Funding Information: The Study of Health in Pomerania (SHIP) is part of the Community Medicine Research net (CMR) ( http://www.medizin.uni-greifswald.de/icm ) of the University Medicine Greifswald, which is supported by the German Federal State of Mecklenburg- West Pomerania. MRI scans in SHIP and SHIP-TREND have been supported by a joint grant from Siemens Healthineers, Erlangen, Germany and the Federal State of Mecklenburg-West Pomerania. Publisher Copyright: {\textcopyright} 2021 Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

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AU - Baune, Bernhard T.

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AU - Greinacher, Andreas

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AU - Levinson, Douglas F.

AU - Lewis, Cathryn M.

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AU - Shi, Jianxin

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AU - Tiemeier, Henning

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AU - Van der Auwera, Sandra

AU - Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium

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N2 - ABO blood types and their corresponding antigens have long been assumed to be related to different human diseases. So far, smaller studies on the relationship between mental disorders and blood types yielded contradicting results. In this study we analyzed the association between ABO blood types and lifetime major depressive disorder (MDD). We performed a pooled analysis with data from 26 cohorts that are part of the MDD working group of the Psychiatric Genomics Consortium (PGC). The dataset included 37,208 individuals of largely European ancestry of which 41.6% were diagnosed with lifetime MDD. ABO blood types were identified using three single nucleotide polymorphisms in the ABO gene: rs505922, rs8176746 and rs8176747. Regression analyses were performed to assess associations between the individual ABO blood types and MDD diagnosis as well as putative interaction effects with sex. The models were adjusted for sex, cohort and the first ten genetic principal components. The percentage of blood type A was slightly lower in cases than controls while blood type O was more prominent in cases. However, these differences were not statistically significant. Our analyses found no evidence of an association between ABO blood types and major depressive disorder.

AB - ABO blood types and their corresponding antigens have long been assumed to be related to different human diseases. So far, smaller studies on the relationship between mental disorders and blood types yielded contradicting results. In this study we analyzed the association between ABO blood types and lifetime major depressive disorder (MDD). We performed a pooled analysis with data from 26 cohorts that are part of the MDD working group of the Psychiatric Genomics Consortium (PGC). The dataset included 37,208 individuals of largely European ancestry of which 41.6% were diagnosed with lifetime MDD. ABO blood types were identified using three single nucleotide polymorphisms in the ABO gene: rs505922, rs8176746 and rs8176747. Regression analyses were performed to assess associations between the individual ABO blood types and MDD diagnosis as well as putative interaction effects with sex. The models were adjusted for sex, cohort and the first ten genetic principal components. The percentage of blood type A was slightly lower in cases than controls while blood type O was more prominent in cases. However, these differences were not statistically significant. Our analyses found no evidence of an association between ABO blood types and major depressive disorder.

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KW - Blood group

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KW - Depression

KW - MDD

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The association between genetically determined ABO blood types and major depressive disorder

Abstract

Bibliographical note

Funding

Keywords

UN SDGs

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Persistent URL (handle)

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