The association between parenting and attachment security is moderated by a polymorphism in the mineralocorticoid receptor gene: Evidence for differential susceptibility

Maartje P.C.M. Luijk; Anne Tharner; Marian J. Bakermans-Kranenburg; Marinus H. van Ijzendoorn; Vincent W.V. Jaddoe; Albert Hofman; Frank C. Verhulst; Henning Tiemeier

doi:10.1016/j.biopsycho.2011.06.005

The association between parenting and attachment security is moderated by a polymorphism in the mineralocorticoid receptor gene: Evidence for differential susceptibility

Maartje P.C.M. Luijk, Anne Tharner, Marian J. Bakermans-Kranenburg^*, Marinus H. van Ijzendoorn, Vincent W.V. Jaddoe, Albert Hofman, Frank C. Verhulst, Henning Tiemeier

^*Corresponding author for this work

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Maternal sensitive responsiveness and extreme insensitivity only partly explain the variance in attachment security. Differences in attachment security may well be rooted in the interplay of genetic variations and environmental factors. The association between parenting (observed sensitive responsiveness and extreme insensitivity) and attachment security (assessed with the Strange Situation Procedure) was hypothesized to be moderated by genes involved in the regulation of the stress response: the glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) genes. A significant G. × E interaction was found: infants carrying the minor MR allele (G) were significantly more securely attached if their mothers showed more sensitive responsiveness and significantly less securely attached if their mothers showed more extremely insensitive behaviors. These associations were not significant for carriers of the AA genotype of MR. Findings are discussed from a differential susceptibility perspective.

Original language	English
Pages (from-to)	37-40
Number of pages	4
Journal	Biological Psychology
Volume	88
Issue number	1
DOIs	https://doi.org/10.1016/j.biopsycho.2011.06.005
Publication status	Published - 1 Sep 2011
Externally published	Yes

Keywords

Attachment
Differential susceptibility
GR
MR
Parenting

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10.1016/j.biopsycho.2011.06.005

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Luijk, M. P. C. M., Tharner, A., Bakermans-Kranenburg, M. J., van Ijzendoorn, M. H., Jaddoe, V. W. V., Hofman, A., Verhulst, F. C., & Tiemeier, H. (2011). The association between parenting and attachment security is moderated by a polymorphism in the mineralocorticoid receptor gene: Evidence for differential susceptibility. Biological Psychology, 88(1), 37-40. https://doi.org/10.1016/j.biopsycho.2011.06.005

Luijk, Maartje P.C.M. ; Tharner, Anne ; Bakermans-Kranenburg, Marian J. ; van Ijzendoorn, Marinus H. ; Jaddoe, Vincent W.V. ; Hofman, Albert ; Verhulst, Frank C. ; Tiemeier, Henning. / The association between parenting and attachment security is moderated by a polymorphism in the mineralocorticoid receptor gene : Evidence for differential susceptibility. In: Biological Psychology. 2011 ; Vol. 88, No. 1. pp. 37-40.

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abstract = "Maternal sensitive responsiveness and extreme insensitivity only partly explain the variance in attachment security. Differences in attachment security may well be rooted in the interplay of genetic variations and environmental factors. The association between parenting (observed sensitive responsiveness and extreme insensitivity) and attachment security (assessed with the Strange Situation Procedure) was hypothesized to be moderated by genes involved in the regulation of the stress response: the glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) genes. A significant G. × E interaction was found: infants carrying the minor MR allele (G) were significantly more securely attached if their mothers showed more sensitive responsiveness and significantly less securely attached if their mothers showed more extremely insensitive behaviors. These associations were not significant for carriers of the AA genotype of MR. Findings are discussed from a differential susceptibility perspective.",

keywords = "Attachment, Differential susceptibility, GR, MR, Parenting",

author = "Luijk, {Maartje P.C.M.} and Anne Tharner and Bakermans-Kranenburg, {Marian J.} and {van Ijzendoorn}, {Marinus H.} and Jaddoe, {Vincent W.V.} and Albert Hofman and Verhulst, {Frank C.} and Henning Tiemeier",

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doi = "10.1016/j.biopsycho.2011.06.005",

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Luijk, MPCM, Tharner, A, Bakermans-Kranenburg, MJ, van Ijzendoorn, MH, Jaddoe, VWV, Hofman, A, Verhulst, FC & Tiemeier, H 2011, 'The association between parenting and attachment security is moderated by a polymorphism in the mineralocorticoid receptor gene: Evidence for differential susceptibility', Biological Psychology, vol. 88, no. 1, pp. 37-40. https://doi.org/10.1016/j.biopsycho.2011.06.005

The association between parenting and attachment security is moderated by a polymorphism in the mineralocorticoid receptor gene : Evidence for differential susceptibility. / Luijk, Maartje P.C.M.; Tharner, Anne; Bakermans-Kranenburg, Marian J.; van Ijzendoorn, Marinus H.; Jaddoe, Vincent W.V.; Hofman, Albert; Verhulst, Frank C.; Tiemeier, Henning.

In: Biological Psychology, Vol. 88, No. 1, 01.09.2011, p. 37-40.

Research output: Contribution to Journal › Article › Academic › peer-review

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The association between parenting and attachment security is moderated by a polymorphism in the mineralocorticoid receptor gene: Evidence for differential susceptibility

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Keywords

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