The association of depression and posttraumatic stress disorder with the metabolic syndrome in a multi-ethnic cohort: the HELIUS study

Marieke J. van Leijden; Brenda W.J.H. Penninx; Charles Agyemang; Miranda Olff; Marcel C. Adriaanse; Marieke B. Snijder

doi:10.1007/s00127-018-1533-y

The association of depression and posttraumatic stress disorder with the metabolic syndrome in a multi-ethnic cohort: the HELIUS study

Marieke J. van Leijden^*
, Brenda W.J.H. Penninx
, Charles Agyemang
, Miranda Olff
, Marcel C. Adriaanse
, Marieke B. Snijder

^*Corresponding author for this work

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Purpose: Depression and posttraumatic stress disorder (PTSD) may be linked to the metabolic syndrome (MetS). Consistency of this association across ethnic groups and the influence of comorbidity of depression/PTSD were examined. Methods: Cross-sectional baseline data from the HELIUS study were used (4527 Dutch, 2999 South-Asian Surinamese, 4058 African Surinamese, 2251 Ghanaian, 3522 Turkish and 3825 Moroccan participants). The Patient Health Questionnaire-9 (PHQ-9) (score range 0–27) measured depressive symptoms. A 9-item questionnaire (score range 0–9) measured PTSD symptoms. The MetS was defined according to the International Diabetes Federation. The association of a depressed mood (PHQ-9 sum score ≥ 10) and severe PTSD symptoms (sum score ≥ 7) with the MetS was examined using logistic regression. Interaction with ethnicity and between a depressed mood and severe PTSD symptoms was tested. Results: A depressed mood was associated with the MetS [OR (95% CI) = 1.37 (1.24–1.51)] in the total sample and consistent across ethnic groups (p values for interaction all > 0.05). Severe PTSD symptoms were significantly associated with the MetS in the Dutch [OR (95% CI) = 1.71 (1.07–2.73)]. The South-Asian Surinamese, Turks and Moroccans showed weaker associations than the Dutch (p values for interaction all < 0.05). A depressed mood and severe PTSD symptoms did not interact in the association with the MetS (p values for interaction > 0.05). Conclusions: A depressed mood was consistently associated with the MetS across ethnic groups, but the association between severe PTSD symptoms and the MetS maybe ethnicity dependent. The association with the MetS was not different in case of depressed mood/severe PTSD symptoms comorbidity.

Original language	English
Pages (from-to)	921-930
Number of pages	10
Journal	Social Psychiatry and Psychiatric Epidemiology
Volume	53
Issue number	9
Early online date	23 May 2018
DOIs	https://doi.org/10.1007/s00127-018-1533-y
Publication status	Published - Sept 2018

Funding

The HELIUS study is conducted by the Academic Medical Center Amsterdam and the Public Health Service of Amsterdam. Both organizations provided core support for HELIUS. The HELIUS study is also funded by the Dutch Heart Foundation (2010T084), the Netherlands Organization for Health Research and Development (ZonMw) (200500003), the European Union (FP-7) (278901), and the European Fund for the Integration of non-EU immigrants (EIF) (2013EIF013). We acknowledge the AMC Biobank for their support in biobank management and high-quality storage of collected samples. We are most grateful to the participants of the HELIUS study and the management team, research nurses, interviewers, research assistants and other staff who have taken part in gathering the data of this study. The authors declare that they have no conflict of interest. Acknowledgements The HELIUS study is conducted by the Academic Medical Center Amsterdam and the Public Health Service of Amsterdam. Both organizations provided core support for HELIUS. The HELIUS study is also funded by the Dutch Heart Foundation (2010T084), the Netherlands Organization for Health Research and Development (ZonMw) (200500003), the European Union (FP-7) (278901), and the European Fund for the Integration of non-EU immigrants (EIF) (2013EIF013). We acknowledge the AMC Biobank for their support in biobank management and high-quality storage of collected samples. We are most grateful to the participants of the HELIUS study and the management team, research nurses, interviewers, research assistants and other staff who have taken part in gathering the data of this study.

Funders	Funder number
Public Health Service of Amsterdam
Netherlands Organization for Health Research and Development
ZonMw	200500003
???publication-publication-funding-organisation-not-added???	16872
Dutch Heart Foundation	2010T084
European Fund	2013EIF013
European Commission	FP-7
Seventh Framework Programme	278901

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Depression
Ethnicity
HELIUS study
Metabolic syndrome
Posttraumatic stress disorder

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10.1007/s00127-018-1533-y

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@article{e59381717dcc42e883674c452a9fbe28,

title = "The association of depression and posttraumatic stress disorder with the metabolic syndrome in a multi-ethnic cohort: the HELIUS study",

abstract = "Purpose: Depression and posttraumatic stress disorder (PTSD) may be linked to the metabolic syndrome (MetS). Consistency of this association across ethnic groups and the influence of comorbidity of depression/PTSD were examined. Methods: Cross-sectional baseline data from the HELIUS study were used (4527 Dutch, 2999 South-Asian Surinamese, 4058 African Surinamese, 2251 Ghanaian, 3522 Turkish and 3825 Moroccan participants). The Patient Health Questionnaire-9 (PHQ-9) (score range 0–27) measured depressive symptoms. A 9-item questionnaire (score range 0–9) measured PTSD symptoms. The MetS was defined according to the International Diabetes Federation. The association of a depressed mood (PHQ-9 sum score ≥ 10) and severe PTSD symptoms (sum score ≥ 7) with the MetS was examined using logistic regression. Interaction with ethnicity and between a depressed mood and severe PTSD symptoms was tested. Results: A depressed mood was associated with the MetS [OR (95\% CI) = 1.37 (1.24–1.51)] in the total sample and consistent across ethnic groups (p values for interaction all > 0.05). Severe PTSD symptoms were significantly associated with the MetS in the Dutch [OR (95\% CI) = 1.71 (1.07–2.73)]. The South-Asian Surinamese, Turks and Moroccans showed weaker associations than the Dutch (p values for interaction all < 0.05). A depressed mood and severe PTSD symptoms did not interact in the association with the MetS (p values for interaction > 0.05). Conclusions: A depressed mood was consistently associated with the MetS across ethnic groups, but the association between severe PTSD symptoms and the MetS maybe ethnicity dependent. The association with the MetS was not different in case of depressed mood/severe PTSD symptoms comorbidity.",

keywords = "Depression, Ethnicity, HELIUS study, Metabolic syndrome, Posttraumatic stress disorder",

author = "\{van Leijden\}, \{Marieke J.\} and Penninx, \{Brenda W.J.H.\} and Charles Agyemang and Miranda Olff and Adriaanse, \{Marcel C.\} and Snijder, \{Marieke B.\}",

year = "2018",

month = sep,

doi = "10.1007/s00127-018-1533-y",

language = "English",

volume = "53",

pages = "921--930",

journal = "Social Psychiatry and Psychiatric Epidemiology",

issn = "0933-7954",

publisher = "D. Steinkopff-Verlag",

number = "9",

}

The association of depression and posttraumatic stress disorder with the metabolic syndrome in a multi-ethnic cohort: the HELIUS study. / van Leijden, Marieke J.; Penninx, Brenda W.J.H.; Agyemang, Charles et al.
In: Social Psychiatry and Psychiatric Epidemiology, Vol. 53, No. 9, 09.2018, p. 921-930.

Research output: Contribution to Journal › Article › Academic › peer-review

TY - JOUR

T1 - The association of depression and posttraumatic stress disorder with the metabolic syndrome in a multi-ethnic cohort: the HELIUS study

AU - van Leijden, Marieke J.

AU - Penninx, Brenda W.J.H.

AU - Agyemang, Charles

AU - Olff, Miranda

AU - Adriaanse, Marcel C.

AU - Snijder, Marieke B.

PY - 2018/9

Y1 - 2018/9

N2 - Purpose: Depression and posttraumatic stress disorder (PTSD) may be linked to the metabolic syndrome (MetS). Consistency of this association across ethnic groups and the influence of comorbidity of depression/PTSD were examined. Methods: Cross-sectional baseline data from the HELIUS study were used (4527 Dutch, 2999 South-Asian Surinamese, 4058 African Surinamese, 2251 Ghanaian, 3522 Turkish and 3825 Moroccan participants). The Patient Health Questionnaire-9 (PHQ-9) (score range 0–27) measured depressive symptoms. A 9-item questionnaire (score range 0–9) measured PTSD symptoms. The MetS was defined according to the International Diabetes Federation. The association of a depressed mood (PHQ-9 sum score ≥ 10) and severe PTSD symptoms (sum score ≥ 7) with the MetS was examined using logistic regression. Interaction with ethnicity and between a depressed mood and severe PTSD symptoms was tested. Results: A depressed mood was associated with the MetS [OR (95% CI) = 1.37 (1.24–1.51)] in the total sample and consistent across ethnic groups (p values for interaction all > 0.05). Severe PTSD symptoms were significantly associated with the MetS in the Dutch [OR (95% CI) = 1.71 (1.07–2.73)]. The South-Asian Surinamese, Turks and Moroccans showed weaker associations than the Dutch (p values for interaction all < 0.05). A depressed mood and severe PTSD symptoms did not interact in the association with the MetS (p values for interaction > 0.05). Conclusions: A depressed mood was consistently associated with the MetS across ethnic groups, but the association between severe PTSD symptoms and the MetS maybe ethnicity dependent. The association with the MetS was not different in case of depressed mood/severe PTSD symptoms comorbidity.

AB - Purpose: Depression and posttraumatic stress disorder (PTSD) may be linked to the metabolic syndrome (MetS). Consistency of this association across ethnic groups and the influence of comorbidity of depression/PTSD were examined. Methods: Cross-sectional baseline data from the HELIUS study were used (4527 Dutch, 2999 South-Asian Surinamese, 4058 African Surinamese, 2251 Ghanaian, 3522 Turkish and 3825 Moroccan participants). The Patient Health Questionnaire-9 (PHQ-9) (score range 0–27) measured depressive symptoms. A 9-item questionnaire (score range 0–9) measured PTSD symptoms. The MetS was defined according to the International Diabetes Federation. The association of a depressed mood (PHQ-9 sum score ≥ 10) and severe PTSD symptoms (sum score ≥ 7) with the MetS was examined using logistic regression. Interaction with ethnicity and between a depressed mood and severe PTSD symptoms was tested. Results: A depressed mood was associated with the MetS [OR (95% CI) = 1.37 (1.24–1.51)] in the total sample and consistent across ethnic groups (p values for interaction all > 0.05). Severe PTSD symptoms were significantly associated with the MetS in the Dutch [OR (95% CI) = 1.71 (1.07–2.73)]. The South-Asian Surinamese, Turks and Moroccans showed weaker associations than the Dutch (p values for interaction all < 0.05). A depressed mood and severe PTSD symptoms did not interact in the association with the MetS (p values for interaction > 0.05). Conclusions: A depressed mood was consistently associated with the MetS across ethnic groups, but the association between severe PTSD symptoms and the MetS maybe ethnicity dependent. The association with the MetS was not different in case of depressed mood/severe PTSD symptoms comorbidity.

KW - Depression

KW - Ethnicity

KW - HELIUS study

KW - Metabolic syndrome

KW - Posttraumatic stress disorder

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DO - 10.1007/s00127-018-1533-y

M3 - Article

AN - SCOPUS:85047258782

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JO - Social Psychiatry and Psychiatric Epidemiology

JF - Social Psychiatry and Psychiatric Epidemiology

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ER -

The association of depression and posttraumatic stress disorder with the metabolic syndrome in a multi-ethnic cohort: the HELIUS study

Abstract

Funding

UN SDGs

Keywords

Access to Document

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