The Association of Genetic Predisposition to Depressive Symptoms with Non-suicidal and Suicidal Self-Injuries

Dominique F Maciejewski; Miguel E Renteria; Abdel Abdellaoui; Sarah E Medland; Lauren R Few; Scott D Gordon; Pamela A F Madden; Grant W Montgomery; Timothy J Trull; Andrew C Heath; Dixie J Statham; Nicholas G Martin; Brendan P Zietsch; Karin J. H. Verweij

doi:10.1007/s10519-016-9809-z

The Association of Genetic Predisposition to Depressive Symptoms with Non-suicidal and Suicidal Self-Injuries

Dominique F Maciejewski, Miguel E Renteria, Abdel Abdellaoui, Sarah E Medland, Lauren R Few, Scott D Gordon, Pamela A F Madden, Grant W Montgomery, Timothy J Trull, Andrew C Heath, Dixie J Statham, Nicholas G Martin, Brendan P Zietsch, Karin J. H. Verweij

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Non-suicidal and suicidal self-injury are very destructive, yet surprisingly common behaviours. Depressed mood is a major risk factor for non-suicidal self-injury (NSSI), suicidal ideation and suicide attempts. We conducted a genetic risk prediction study to examine the polygenic overlap of depressive symptoms with lifetime NSSI, suicidal ideation, and suicide attempts in a sample of 6237 Australian adult twins and their family members (3740 females, mean age = 42.4 years). Polygenic risk scores for depressive symptoms significantly predicted suicidal ideation, and some predictive ability was found for suicide attempts; the polygenic risk scores explained a significant amount of variance in suicidal ideation (lowest p = 0.008, explained variance ranging from 0.10 to 0.16 %) and, less consistently, in suicide attempts (lowest p = 0.04, explained variance ranging from 0.12 to 0.23 %). Polygenic risk scores did not significantly predict NSSI. Results highlight that individuals genetically predisposed to depression are also more likely to experience suicidal ideation/behaviour, whereas we found no evidence that this is also the case for NSSI.

Original language	English
Pages (from-to)	3-10
Number of pages	8
Journal	Behavior Genetics
Volume	47
Issue number	1
DOIs	https://doi.org/10.1007/s10519-016-9809-z
Publication status	Published - Jan 2017

Funding

Supported by National Institutes of Health Grants AA013326, AA07535, AA0758O, AA07728, AA10249, AA13320, AA13321, AA14041, AA11998, AA17688, DA00272, DA012854, DA07261, DA018267, DA018660, DA23668 and DA019951; by Grants from the Australian National Health and Medical Research Council (241944, 339462, 389927, 389875, 389891, 389892, 389938, 442915, 442981, 496739, 552485, 552498, 628911 and 1047956); by Grants from the Australian Research Council (A7960034, A79906588, A79801419, DP0770096, DP0212016 and DP0343921); and by the 5th Framework Programme (FP-5) GenomEUtwin Project (QLG2-CT-2002-01254). This research was further supported by the Centre for Research Excellence on Suicide Prevention (CRESP-Australia). KJHV is supported in part by a 2014 NARSAD Young Investigator Grant from the Brain & Behavior Research Foundation.

Funders	Funder number
CRESP-Australia
Centre for Research Excellence on Suicide Prevention
National Institutes of Health	AA14041, DA019951, DA018267, AA13320, AA07728, DA018660, AA013326, AA10249, AA11998, DA23668, DA012854, DA07261, AA13321, AA0758O, AA17688, DA00272
National Institute on Alcohol Abuse and Alcoholism	R01AA007535
Brain and Behavior Research Foundation
National Alliance for Research on Schizophrenia and Depression
Australian Research Council	A7960034, DP0212016, A79801419, DP0343921, A79906588, DP0770096
National Health and Medical Research Council	339462, 1047956, 389892, 389891, 241944, 552485, 442981, 552498, 496739, 389875, 442915, 389927, 389938, 628911
Fifth Framework Programme	FP-5, QLG2-CT-2002-01254

Keywords

Journal Article

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Maciejewski, D. F., Renteria, M. E., Abdellaoui, A., Medland, S. E., Few, L. R., Gordon, S. D., Madden, P. A. F., Montgomery, G. W., Trull, T. J., Heath, A. C., Statham, D. J., Martin, N. G., Zietsch, B. P., & Verweij, K. J. H. (2017). The Association of Genetic Predisposition to Depressive Symptoms with Non-suicidal and Suicidal Self-Injuries. Behavior Genetics, 47(1), 3-10. https://doi.org/10.1007/s10519-016-9809-z

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abstract = "Non-suicidal and suicidal self-injury are very destructive, yet surprisingly common behaviours. Depressed mood is a major risk factor for non-suicidal self-injury (NSSI), suicidal ideation and suicide attempts. We conducted a genetic risk prediction study to examine the polygenic overlap of depressive symptoms with lifetime NSSI, suicidal ideation, and suicide attempts in a sample of 6237 Australian adult twins and their family members (3740 females, mean age = 42.4 years). Polygenic risk scores for depressive symptoms significantly predicted suicidal ideation, and some predictive ability was found for suicide attempts; the polygenic risk scores explained a significant amount of variance in suicidal ideation (lowest p = 0.008, explained variance ranging from 0.10 to 0.16 \%) and, less consistently, in suicide attempts (lowest p = 0.04, explained variance ranging from 0.12 to 0.23 \%). Polygenic risk scores did not significantly predict NSSI. Results highlight that individuals genetically predisposed to depression are also more likely to experience suicidal ideation/behaviour, whereas we found no evidence that this is also the case for NSSI.",

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Maciejewski, DF, Renteria, ME, Abdellaoui, A, Medland, SE, Few, LR, Gordon, SD, Madden, PAF, Montgomery, GW, Trull, TJ, Heath, AC, Statham, DJ, Martin, NG, Zietsch, BP & Verweij, KJH 2017, 'The Association of Genetic Predisposition to Depressive Symptoms with Non-suicidal and Suicidal Self-Injuries', Behavior Genetics, vol. 47, no. 1, pp. 3-10. https://doi.org/10.1007/s10519-016-9809-z

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AU - Abdellaoui, Abdel

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AU - Few, Lauren R

AU - Gordon, Scott D

AU - Madden, Pamela A F

AU - Montgomery, Grant W

AU - Trull, Timothy J

AU - Heath, Andrew C

AU - Statham, Dixie J

AU - Martin, Nicholas G

AU - Zietsch, Brendan P

AU - Verweij, Karin J. H.

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The Association of Genetic Predisposition to Depressive Symptoms with Non-suicidal and Suicidal Self-Injuries

Abstract

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Keywords

UN SDGs

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