The Bacillus subtilis transition state regulator AbrB binds to the -35 promoter region of comK

Leendert W. Hamoen*, Daisy Kausche, Mohamed A. Marahiel, Douwe Van Sinderen, Gerard Venema, Pascale Serror

*Corresponding author for this work

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Genetic competence is a differentiation process initiated by Bacillus subtilis as a result of nutritional deprivation, and is controlled by a complex signal transduction cascade. The promoter of comK, encoding the competence transcription factor, is regulated by at least four different transcription factors: Rok, CodY, DegU and ComK itself. Genetic data have shown that comK expression is influenced by the transition state regulator AbrB as well. In this paper we show that AbrB binds specifically to the comK promoter and covers the RNA polymerase binding site, making it the fifth transcription factor regulating the activity of the comK promoter.

Original languageEnglish
Pages (from-to)299-304
Number of pages6
JournalFEMS Microbiology Letters
Volume218
Issue number2
DOIs
Publication statusPublished - 28 Jan 2003
Externally publishedYes

Keywords

  • AbrB
  • CodY
  • ComK
  • Competence
  • DegU
  • Rok

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