The BAR Domain Protein PICK1 Controls Vesicle Number and Size in Adrenal Chromaffin Cells

P.S. Pinheiro; A.M. Jansen; H. de Wit; B. Tawfik; K.L. Madsen; M. Verhage; U. Gether; J.B. Sørensen

doi:10.1523/JNEUROSCI.5132-13.2014

The BAR Domain Protein PICK1 Controls Vesicle Number and Size in Adrenal Chromaffin Cells

P.S. Pinheiro
, A.M. Jansen
, H. de Wit
, B. Tawfik
, K.L. Madsen
, M. Verhage
, U. Gether
, J.B. Sørensen

Functional Genomics

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Protein Interacting with C Kinase 1 (PICK1) is a Bin/Amphiphysin/Rvs (BAR) domain protein involved in AMPA receptor trafficking. Here, we identify a selective role for PICK1 in the biogenesis of large, dense core vesicles (LDCVs) in mouse chromaffin cells. PICK1 colocalized with syntaxin-6, a marker for immature granules. In chromaffin cells isolated from a PICK1 knockout (KO) mouse the amount of exocytosis was reduced, while release kinetics and Ca

Original language	English
Pages (from-to)	10688-10700
Journal	The Journal of Neuroscience
Volume	34
Issue number	32
DOIs	https://doi.org/10.1523/JNEUROSCI.5132-13.2014
Publication status	Published - 2014

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10.1523/JNEUROSCI.5132-13.2014

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title = "The BAR Domain Protein PICK1 Controls Vesicle Number and Size in Adrenal Chromaffin Cells",

abstract = "Protein Interacting with C Kinase 1 (PICK1) is a Bin/Amphiphysin/Rvs (BAR) domain protein involved in AMPA receptor trafficking. Here, we identify a selective role for PICK1 in the biogenesis of large, dense core vesicles (LDCVs) in mouse chromaffin cells. PICK1 colocalized with syntaxin-6, a marker for immature granules. In chromaffin cells isolated from a PICK1 knockout (KO) mouse the amount of exocytosis was reduced, while release kinetics and Ca",

author = "P.S. Pinheiro and A.M. Jansen and \{de Wit\}, H. and B. Tawfik and K.L. Madsen and M. Verhage and U. Gether and J.B. S{\o}rensen",

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doi = "10.1523/JNEUROSCI.5132-13.2014",

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T1 - The BAR Domain Protein PICK1 Controls Vesicle Number and Size in Adrenal Chromaffin Cells

AU - Pinheiro, P.S.

AU - Jansen, A.M.

AU - de Wit, H.

AU - Tawfik, B.

AU - Madsen, K.L.

AU - Verhage, M.

AU - Gether, U.

AU - Sørensen, J.B.

PY - 2014

Y1 - 2014

N2 - Protein Interacting with C Kinase 1 (PICK1) is a Bin/Amphiphysin/Rvs (BAR) domain protein involved in AMPA receptor trafficking. Here, we identify a selective role for PICK1 in the biogenesis of large, dense core vesicles (LDCVs) in mouse chromaffin cells. PICK1 colocalized with syntaxin-6, a marker for immature granules. In chromaffin cells isolated from a PICK1 knockout (KO) mouse the amount of exocytosis was reduced, while release kinetics and Ca

AB - Protein Interacting with C Kinase 1 (PICK1) is a Bin/Amphiphysin/Rvs (BAR) domain protein involved in AMPA receptor trafficking. Here, we identify a selective role for PICK1 in the biogenesis of large, dense core vesicles (LDCVs) in mouse chromaffin cells. PICK1 colocalized with syntaxin-6, a marker for immature granules. In chromaffin cells isolated from a PICK1 knockout (KO) mouse the amount of exocytosis was reduced, while release kinetics and Ca

U2 - 10.1523/JNEUROSCI.5132-13.2014

DO - 10.1523/JNEUROSCI.5132-13.2014

M3 - Article

SN - 0270-6474

VL - 34

SP - 10688

EP - 10700

JO - The Journal of Neuroscience

JF - The Journal of Neuroscience

IS - 32

ER -

The BAR Domain Protein PICK1 Controls Vesicle Number and Size in Adrenal Chromaffin Cells

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