The blood pressure effect and related plasma levels of flavan-3-ols in spontaneously hypertensive rats

M. Quiñones, M. Margalef, A. Arola-Arnal, B. Muguerza, M. Miguel, A. Aleixandre

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

© The Royal Society of Chemistry.We studied the short-term antihypertensive effect of flavan-3-ols (-)-epicatechin, (+)-catechin and (-)-catechin, in spontaneously hypertensive rats (SHR). Plasma metabolites and the corresponding plasma antioxidant capacity were determined. All the assayed flavan-3-ols decreased systolic blood pressure (SBP) in SHR. Their antihypertensive effects were less pronounced than that of Captopril (50 mg kg-1) and were not shown in normotensive Wistar-Kyoto rats. 6 mg kg-1 (-)-epicatechin caused the maximum decrease in SBP. The maximum effects of the catechin monomers were observed post-administration of 0.5 mg kg-1 of flavan-3-ols, (-)-catechin being the least effective among the three assayed compounds. Glucuronide and methyl glucuronide metabolites were obtained in the flavan-3-ol treated SHR, but it was not possible to relate the antihypertensive effect of the assayed flavan-3-ols with a concrete plasma metabolite or with their antioxidant effect. In conclusion, the studied flavan-3-ols could be responsible for the antihypertensive effect of cocoa products.
Original languageEnglish
Pages (from-to)3479-3489
JournalFood and Function
Volume6
Issue number11
DOIs
Publication statusPublished - 1 Nov 2015
Externally publishedYes

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