The Capsular Polysaccharide Obstructs Wall Teichoic Acid Functions in Staphylococcus aureus

Funding

Financial support. This work was supported by the Deutsche Forschungsgemeinschaft program SPP2330 (grant numbers 464612409 to C. Wo. and 465126486 to A. P.), project SFB766 (grant number 32152271 to C. Wo. and C. We.), and infrastructural funding Cluster of Excellence EXC 2124 Controlling Microbes to Fight Infections (grant number 390838134 to A. P.). E. L. was supported by Land Baden-Württemberg program Promotionsstipendium nach dem Landesgraduiertenförderungsgesetz, Baden-Württemberg, Germany. R. v. D. was supported by the Nederlandse Organisatie voor Wetenschappelijk Onderzoek (Rubicon grant number 45219208), and the European Molecular Biology Organization (grant number ALTF 757-2019). We thank Nina van Sorge (Amsterdam UMC, The Netherlands) for kindly providing anti-WTA Fab-antibody; Cosima Hirt and Dorothee Kretschmer for assistance and scientific discussion regarding the animal experiments; Ellen Daibler and Vittoria Bisanzio for technical assistance during the revision; Simon Heilbronner for help with the ethics proposal; and Libera Lo Presti for scientific discussions and editing of the manuscript. Mutants from the Nebraska library were obtained through the Network on Antimicrobial Resistance in Staphylococcus aureus program. This work was supported by the Deutsche Forschungsgemeinschaft program SPP2330 (grant numbers 464612409 to C. Wo. and 465126486 to A. P.), project SFB766 (grant number 32152271 to C. Wo. and C. We.), and infrastructural funding Cluster of Excellence EXC 2124 Controlling Microbes to Fight Infections (grant number 390838134 to A. P.). E. L. was supported by Land Baden- Württemberg program Promotionsstipendium nach dem Landesgraduiertenförde-rungsgesetz, Baden-Württemberg, Germany. R. v. D. was supported by the Nederlandse Organisatie voor Wetenschappelijk Onderzoek (Rubicon grant number 45219208), and the European Molecular Biology Organization (grant number ALTF 757-2019).